ArticleJournal of clinical immunology2017
Increased Incidence of Fatigue in Patients with Primary Immunodeficiency Disorders: Prevalence and Associations Within the US Immunodeficiency Network Registry.
Article in Journal of clinical immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Targeted Therapy for Complex Lymphatic Anomalies in Patients with Noonan Syndrome and Related Disorders.International journal of molecular sciences · 2025Article
- Assessment of Sleep Disorders in Patients with CVID.Journal of clinical immunology · 2024Article
- High Prevalence of Long COVID in Common Variable Immunodeficiency: An Italian Multicentric Study.Journal of clinical immunology · 2024Observational
- Perceived Sleep Quality in Individuals with Inborn Errors of Immunity.Journal of clinical immunology · 2023Article
- Prevalence and Impact of Fatigue in Children with Primary Immunodeficiency Disorders: a Quantitative Single-Center Study.Journal of clinical immunology · 2022Observational
- Psychological Symptoms in Primary Immunodeficiencies: a Common Comorbidity?Journal of clinical immunology · 2022Article
- Subjective sleep quality and fatigue assessment in Polish adult patients with primary immunodeficiencies: A pilot study.Frontiers in immunology · 2022Article
- Spectrum of Disease Manifestations in Patients with Selective Immunoglobulin E Deficiency.Journal of clinical medicine · 2021Article
- Severe Fatigue Is Common Among Pediatric Patients with Primary Immunodeficiency and Is Not Related to Disease Activity.Journal of clinical immunology · 2021Article
- Infection Phenotypes Among Patients with Primary Antibody Deficiency Mined from a US Patient Registry.Journal of clinical immunology · 2021Article
- Fatigue Is Common in Immunoglobulin G Subclass Deficiency and Correlates With Inflammatory Response and Need for Immunoglobulin Replacement Therapy.Frontiers in immunology · 2021Article
- Primary immunodeficiency diseases treated with immunoglobulin and associated comorbidities.Allergy and asthma proceedings · 2021Article
- Hallmarks of Cancers: Primary Antibody DeficiencyFrontiers in immunology · 2021Review
- PROMIS-29 survey confirms major impact of fatigue on health-related quality of life in common variable immunodeficiency.Immunologic research · 2020Article
- The Importance of Primary Immune Deficiency Registries: The United States Immunodeficiency Network Registry.Immunology and allergy clinics of North America · 2020Review
- Health-Related Quality of Life and Multidimensional Fatigue Scale in Children with Primary Immunodeficiencies.Journal of clinical immunology · 2020Article
- The presence of overlapping quality of life symptoms in primary antibody deficiency (PAD) and chronic fatigue syndrome (CFS).Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2020Article
- Fatigue, Sleep, and Autoimmune and Related Disorders.Frontiers in immunology · 2019Review
- Fatigue and the wear-off effect in adult patients with common variable immunodeficiency.Clinical and experimental immunology · 2018Article
- Treatment Satisfaction with Subcutaneous Immunoglobulin Replacement Therapy in Patients with Primary Immunodeficiency: a Pooled Analysis of Six Hizentra® Studies.Journal of clinical immunology · 2018Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
introductionPatients with primary immunodeficiency (PID) often report fatigue, yet this symptom has not been studied in PID. Fatigue affects 6-7.5% of healthy adults. The goal of this study is to estimate the prevalence of fatigue in patients with PID and investigate its associated factors.
methodsWe analyzed 2537 PID patients registered in USIDNET to determine responses to the field "fatigue" in the core registry form. Demographics, immune phenotypes, and comorbid conditions were compared between fatigued and non-fatigued patients to identify relevant associations and potential drivers. A focused analysis was performed for patients with predominantly antibody deficiency disorders (PADs).
resultsFatigue was reported in 25.9% (95% CI 23.7-28.3) of PAD patients, compared to 6.4% (95% CI 4.9-8.2) of non-PAD. Patients with common variable immunodeficiency (CVID) had the highest prevalence of fatigue (p < 0.001) among all PID diagnoses. Other factors that were associated with a higher rate of fatigue among PAD patients included female sex, higher BMI, depression, bronchiectasis, and autoimmunity. Additionally, fatigued PAD patients had lower absolute lymphocyte, CD3, CD4, and CD8 counts compared to non-fatigued patients.
conclusionOur findings suggest that fatigue is overrepresented in PAD patients. Prospective studies to estimate prevalence, risk factors, and fatigue etiology in PID are warranted, so therapeutic interventions can be considered.
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