ArticleLasers in medical science2017
Laser-assisted topical corticosteroid delivery for the treatment of keloids.
Article in Lasers in medical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Keloid treatments: an evidence-based systematic review of recent advances.Systematic reviews · 2023Pooled it
- Efficacy and safety of laser combination therapy and laser alone therapy for keloid: a systematic review and meta-analysis.Lasers in medical science · 2022Pooled it
- A systematic review of randomised controlled trials investigating laser assisted drug delivery for the treatment of keloid and hypertrophic scars.Lasers in medical science · 2022Pooled it
- Combination of fractional carbon dioxide laser and topical triamcinolone vs intralesional triamcinolone for keloid treatment: A randomised clinical trial.International wound journal · 2022Trial
- Hypertrophic Scar Outcomes in Fractional Laser Monotherapy Versus Fractional Laser-Assisted Topical Corticosteroid Delivery: A Randomized Clinical Trial.Acta dermato-venereologica · 2021Trial
- Energy-based devices for enhanced transdermal drug delivery in pathological scars: A review.Lasers in medical science · 2026Review
- Fractional COLasers in surgery and medicine · 2026Observational
- Laser-Assisted Drug Delivery for Hypertrophic Scar Treatment: A Scoping Review.Journal of burn care & research : official publication of the American Burn Association · 2026Article
- Fractional erbium-doped yttrium aluminum garnet laser-assisted drug delivery: impact of triamcinolone acetonide formulation on drug permeation.Drug delivery and translational research · 2025Article
- Manual Fractional Technology with COAesthetic plastic surgery · 2025Article
- The effectiveness of fractional laser-assisted photodynamic therapy utilizing methylene blue for the treatment of keloids.Archives of dermatological research · 2025Article
- The effects of systemic diseases, genetic disorders and lifestyle on keloids.International wound journal · 2024Review
- Future Directions About Keloid Scars Based on Pathogenesis and Therapies.Clinical, cosmetic and investigational dermatology · 2024Review
- [Opinion on the photoelectric therapy of scars].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023Article
- Hypertrophic Scars and Keloids: Advances in Treatment and Review of Established Therapies.American journal of clinical dermatology · 2023Review
- The application of corticosteroids for pathological scar prevention and treatment: current review and update.Burns & trauma · 2023Article
- Laser microporation facilitates topical drug delivery: a comprehensive review about preclinical development and clinical application.Expert opinion on drug delivery · 2023Review
- Combination of Fractional Er:YAG Laser, Pulsed Dye Laser, and Intralesional Triamcinolone With 5-Fluorouracil for Keloid Treatment.Journal of lasers in medical sciences · 2023Article
- Laser-Assisted Drug Delivery: A Systematic Review of Safety and Adverse Events.Pharmaceutics · 2022Review
- Evaluating the Efficacy of the Er,Cr:YSGG Fractional Laser Before Treatment With Triamcinolone NN Ointment in Oral Lichen Planus Lesions.Journal of lasers in medical sciences · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Laser-assisted drug delivery has generated intense interest. The objectives of this study are to evaluate the clinical benefit of laser-assisted corticosteroid delivery and to compare this technique to corticosteroid intralesional injection, a standard treatment for keloids. Patients with keloids on the left shoulder after BCG vaccination were enrolled in this study. The entire lesion was first treated with an ablative fractional erbium-YAG laser. After this treatment, the lesion was divided into two halves. The first half received an intralesional injection of corticosteroid, whereas the second half received topical application of corticosteroids that were occluded for 3 hours. Four treatment sessions were conducted, with treatments occurring once every 6 weeks. Treatment outcomes were evaluated using the Vancouver Scar Scale (VSS). Pain was self-assessed by the patient during the procedure. The mean keloid VSS score before treatment was 8.59 ± 1.23 for the corticosteroid injection site and 8.31 ± 2.09 for the topical site. After treatment, the mean keloid VSS score was decreased on both sides (4.56 ± 1.09 vs 5.02 ± 0.87, respectively, P > 0.05). Patients rated their satisfaction level as "moderate" on both sides. However, the mean pain score was 1.1 out of 10 on the topical side versus 6.1 on the corticosteroid injection site. The combination of ablative fractional laser treatment and topical corticosteroid application is a promising modality for the treatment of keloids. Moreover, this procedure was not associated with any serious adverse reactions or unbearable pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.