Evidence map›Paper›PMID 28124184›Full record

ArticleJournal of mammary gland biology and neoplasia2017

Reelin Deficiency Delays Mammary Tumor Growth and Metastatic Progression.

Elvira Khialeeva, Joan W Chou, Denise E Allen, Alec M Chiu, Steven J Bensinger, Ellen M Carpenter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of mammary gland biology and neoplasia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Reelin Promotes Cisplatin Resistance by Induction of Epithelial-Mesenchymal Transition via p38/GSK3β/Snail Signaling in Non-Small Cell Lung Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Elvira KhialeevaMolecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA. ekhiale@ucla.edu.
Joan W ChouDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.
Denise E AllenDepartment of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, CA, USA.
Alec M ChiuDepartment of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA, USA.
Steven J BensingerDepartment of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, USA.
Ellen M CarpenterMolecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA.
University of California, Los Angeles · US

Funding

UCLA Center for Translational Research in Neurodevelopment: UC-TRaNU54HD087101 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCCRACKEN, JAMES T. · 2016 to 2020
$6.5M
Dab1 expression and activity in mammary epithelial cells.R03HD075840 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CARPENTER, ELLEN M. · 2014 to 2015
$152k
NICHD NIH HHS R03 HD075840NICHD NIH HHS U54 HD087101
6 · The paper itself

Abstract

Reelin is a regulator of cell migration in the nervous system, and has other functions in the development of a number of non-neuronal tissues. In addition, alterations in reelin expression levels have been reported in breast, pancreatic, liver, gastric, and other cancers. Reelin is normally expressed in mammary gland stromal cells, but whether stromal reelin contributes to breast cancer progression is unknown. Herein, we used a syngeneic mouse mammary tumor transplantation model to examine the impact of host-derived reelin on breast cancer progression. We found that transplanted syngeneic tumors grew more slowly in reelin-deficient (rl

Indexed as

AnimalsBreastBreast NeoplasmsCell Adhesion Molecules, NeuronalCell LineCell Line, TumorCell ProliferationCytokinesDisease ProgressionExtracellular Matrix ProteinsFemaleGene ExpressionHEK293 CellsHumansMacrophagesMammary Neoplasms, AnimalCell Adhesion Molecules, NeuronalCytokinesExtracellular Matrix ProteinsNerve Tissue ProteinsReelin ProteinRELN protein, humanReln protein, mouseSerine Endopeptidases4T1Breast cancerReelinTumor-associated macrophage

Identifiers

PMID28124184
PMCPMC5319436
OpenAlexW2580972048

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.