Evidence map›Paper›PMID 28124031›Full record

ArticleJournal of clinical & experimental immunology2016

Expansion and productive HIV-1 infection of Foxp3 positive CD4 T cells at pleural sites of HIV/TB co-infection.

Christina S Hirsch, Joy Baseke, John Lusiba Kafuluma, Mary Nserko, Harriet Mayanja-Kizza, Zahra Toossi

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical & experimental immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Christina S HirschDivision of Infectious Diseases, Case Western Reserve University, Cleveland OH.
Joy BasekeJoint Clinical Research Center, Kampala, Uganda.
John Lusiba KafulumaMakerere University, Kampala, Uganda, National Tuberculosis and Leprosy Program, Kampala, Uganda.
Mary NserkoMakerere University, Kampala, Uganda, National Tuberculosis and Leprosy Program, Kampala, Uganda.
Harriet Mayanja-KizzaJoint Clinical Research Center, Kampala, Uganda; Makerere University, Kampala, Uganda, National Tuberculosis and Leprosy Program, Kampala, Uganda.
Zahra ToossiDivision of Infectious Diseases, Case Western Reserve University, Cleveland OH; Veterans Affairs Medical Center, Cleveland, OH.
Joint Clinical Research Centre · UG

Funding

INTERACTION OF M TUBERCULOSIS AND HIV IN THE LUNGR01HL051636 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI TOOSSI, ZAHRA TOOSSI · 1993 to 2014
$4.9M
Impact of Tuberculosis on HIV DiseaseR56HL051636 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI TOOSSI, ZAHRA TOOSSI · 2009 to 2009
$305k
NHLBI NIH HHS R01 HL051636NHLBI NIH HHS R56 HL051636NIAID NIH HHS N01 AI070022
6 · The paper itself

Abstract

backgroundCD4 T-cells expressing Foxp3 are expanded systemically during active tuberculosis (TB) regardless of HIV-1 co-infection. Foxp3

methodsPleural fluid mononuclear cells (PFMC) from HIV/TB co-infected patients with pleural TB were characterized by immune-staining and FACS analysis for surface markers CD4, CD127, CCR5, CXCR4, HLA-DR and intracellular expression of Foxp3, HIVp24, IFN-γ and Bcl-2. Whole PFMC and bead separated CD4

resultsHigh numbers of HIV-1 p24 positive Foxp3

conclusionFoxp3

Indexed as

ApoptosisBcl-2Foxp3HIV-1 LTRHIV-1 p24HIV/TB co-infectionPleural TBRegulatory T-cell

Identifiers

PMID28124031
PMCPMC5258182
OpenAlexW2585975522

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.