Evidence map›Paper›PMID 28123829›Full record

ArticleTranslational neuroscience2016

Enhancing attention in neurodegenerative diseases: current therapies and future directions.

Kanchan Sharma, Thomas Davis, Elizabeth Coulthard

Open access · goldAbstract read
In one paragraph

Article in Translational neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Kanchan SharmaReMemBr group (Research in Memory, the Brain and dementia) School of Clinical Sciences, University of Bristol Level 1, Learning and Research Southmead Hospital, Bristol BS10 5NB, United Kingdom.
Thomas DavisReMemBr group (Research in Memory, the Brain and dementia) School of Clinical Sciences, University of Bristol Level 1, Learning and Research Southmead Hospital, Bristol BS10 5NB, United Kingdom.
Elizabeth CoulthardReMemBr group (Research in Memory, the Brain and dementia) School of Clinical Sciences, University of Bristol Level 1, Learning and Research Southmead Hospital, Bristol BS10 5NB, United Kingdom.
Southmead Hospital · GBUniversity of Bristol · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We all experience at least occasional lapses in attention but in some neurological conditions, loss of attention is pervasive and debilitating. Treating deficits in attention first requires an understanding of the neurobiology of attention, which we now understand to be a set of different cognitive processes. Cholinesterase inhibitors are already established as effective attentional enhancers used in the treatment of certain dementias. Other stimulant agents such as modafanil, amphetamine and methylphenidate have demonstrated limited success in healthy individuals where attention is already optimal and clinical trials in patients with neurological disease are sparse. Dietary and lifestyle changes are gaining increasing prominence, as are experimental treatments such as deep brain stimulation and transcranial magnetic stimulation. As the therapeutic arsenal widens, clinicians will be able to match specific treatments to selective deficits in attention, giving patients a tailored management plan. Here we review common diseases that impair attention and emphasise how an understanding of attentional processing within the brain might lead to improved therapeutic strategies.

Indexed as

Alerting networkAttention networkCaffeineExecutive networkMeditationNeurodegeneration

Identifiers

PMID28123829
PMCPMC5234525
OpenAlexW2546025392

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.