ArticleTranslational neuroscience2016
Serum C-reactive protein, fibrinogen and D-dimer in patients with progressive cerebral infarction.
Article in Translational neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Blood-Based Biomarkers for Post-Stroke Cognitive Impairment.Current issues in molecular biology · 2026Review
- C-reactive protein-to-lymphocyte ratio and stroke: associations with prevalence and subsequent mortality in NHANES 1999-2010.Clinical and experimental medicine · 2026Article
- The Joint Effect of C-Reactive Protein and Fibrinogen in Predicting Intracranial Hypertension of Cerebral Venous Sinus Thrombosis Patients.Journal of inflammation research · 2026Article
- Association Between Thromboelastography and Coagulation for Disease Severity Evaluation in Patients With Lower Extremity Arteriosclerosis Obliterans.Journal of clinical laboratory analysis · 2025Article
- Inflammatory marker profiles and in-hospital neurological deterioration in patients with acute minor ischemic stroke.CNS neuroscience & therapeutics · 2024Article
- Preprocedural D-Dimer Level as a Predictor of First-Pass Recanalization and Functional Outcome in Endovascular Treatment of Acute Ischemic Stroke.Journal of clinical medicine · 2023Article
- Thromboelastography predicts dual antiplatelet therapy-related hemorrhage in patients with acute ischemic stroke.Journal of neurointerventional surgery · 2022Article
- A Systematic Review of Body Fluids Biomarkers Associated With Early Neurological Deterioration Following Acute Ischemic Stroke.Frontiers in aging neuroscience · 2022Review
- The value of diffusion weighted imaging in predicting the clinical progression of perforator artery cerebral infarction.NeuroImage. Clinical · 2022Article
- Observation of the Effect of Nursing BPR on Thrombolytic Efficacy and Prognosis of Patients with Cerebral Infarction Based on CT Images.Contrast media & molecular imaging · 2022Article
- VEGF to CITED2 ratio predicts the collateral circulation of acute ischemic stroke.Frontiers in neurology · 2022Article
- Efficacy of using thromboelastography to detect coagulation function and platelet function in patients with acute cerebral infarction.Acta neurologica Belgica · 2021Article
- Changes and significance of serum CXCL-16, GDF-15, PLA-2 levels in patients with cerebral infarction.American journal of translational research · 2021Article
- Prazosin blocks apoptosis of endothelial progenitor cells through downregulating the Akt/NF-κB signaling pathway in a rat cerebral infarction model.Experimental and therapeutic medicine · 2020Article
- Relationship between fibrinogen level and its regulatory gene with Alzheimer's disease and vascular dementia.The Journal of international medical research · 2020Article
- High levels of plasma fibrinogen are related to post-stroke cognitive impairment.Brain and behavior · 2019Article
- Elevated plasma D-dimer levels are associated with short-term poor outcome in patients with acute ischemic stroke: a prospective, observational study.BMC neurology · 2019Observational
- The role of oxidative stress as a risk factor for rupture of posterior inferior cerebellar artery aneurysms.Molecular biology reports · 2018Article
- Thromboelastography-derived parameters for the prediction of acute thromboembolism following non-steroidal anti-inflammatory drug-induced gastrointestinal bleeding: A retrospective study.Experimental and therapeutic medicine · 2018Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveProgressive cerebral infarctions increase mortality and functional disability through mechanisms which have yet to be completely understood. The goal of this study was to explore the dynamic changes of serum C-reactive protein (CRP), fibrinogen (FIB) and D-dimer (D-D) in order to better characterize progressive cerebral infarction.
methodsThe amount of serum CRP, FIB and D-D was measured in 82 patients with progressive cerebral infarction by taking samples from the internal carotid artery (progressive group), and in 186 patients with non-progressive cerebral infarction (non-progressive group) by using an automatic biochemical analyzer during the next day (day 1), day 3, day 7, and day 14 after being admitted to hospital. Carotid vascular ultrasound and neurological deficit score (National Institutes of Health Stroke Scale, NIHSS) were also recorded.
resultsCarotid stenosis ratio was significantly higher in the progressive group than in the non-progressive group (P < 0.01) on admission. In the progressive group, CRP increased significantly on day 3, followed by a decline on day 7 and day 14, but was significantly higher than those in the non-progressive group (P < 0.01). The levels of FIB and D-D increased in the progressive group more than those in the non-progressive group on day 3, day 7, and day 14 (P < 0.01). The progressive group patients' NIHSS score gradually increased after admission, which was opposite to the non-progressive group patients whom followed a downward trend. The difference between these two groups was significant (P < 0.01).
conclusionObserving changes of CRP, FIB and D-D may contribute to early identification and timely treatment of progressing ischemic strokes.
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