ReviewTranslational neuroscience2015
Identification of biological markers for better characterization of older subjects with physical frailty and sarcopenia.
Review in Translational neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exercise for frailty research frontiers: a bibliometric analysis and systematic review.Frontiers in medicine · 2024Pooled it
- Bibliometric and scientometric analysis on biomarkers and molecular mechanisms for physical frailty and sarcopenia.Frontiers in medicine · 2024Article
- Extracellular Vesicles and Their Zeta Potential as Future Markers Associated with Nutrition and Molecular Biomarkers in Breast Cancer.International journal of molecular sciences · 2023Article
- Orthostatic hypotension is associated with malnutrition diagnosed by GLIM in elderly hypertensive patients.BMC geriatrics · 2022Article
- Article
- Review
- The Effect of Nordic Walking Training with Poles with an Integrated Resistance Shock Absorber on the Functional Fitness of Women over the Age of 60.International journal of environmental research and public health · 2020Article
- Serum creatinine and cystatin C-based index can be a screening biomarker for sarcopenia in older population.European geriatric medicine · 2019Article
- Balancing Weight Loss and Sarcopenia in Elderly Patients With Peripheral Artery Disease.Journal of the American Heart Association · 2019Article
- Frailty and the Metabolic Syndrome - Results of the Berlin Aging Study II (BASE-II).The Journal of frailty & aging · 2019Article
- Editorial: Weight Loss is a Major Cause of Frailty.The journal of nutrition, health & aging · 2017Article
Corrections and comments
- Retraction · 2020-09-11Plagiarism of/in Article ·
- Retracted
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Population aging is rapidly accelerating worldwide; however, longer life expectancy is not the only public health goal. Indeed, extended lifetime involves maintaining function and the capacity of living independently. Sarcopenia and physical frailty are both highly relevant entities with regards to functionality and autonomy of older adults. The concepts and definitions of frailty and sarcopenia have largely been revised over the years. Sarcopenia is an age-related progressive and generalized loss of skeletal muscle mass and strength. On the other hand, frailty is a state of increased vulnerability to stressors, responsible for exposing the older person to enhanced risk of adverse outcomes. Physical frailty and sarcopenia substantially overlap and several adverse outcomes of frailty are likely mediated by sarcopenia. Indeed, the concepts of sarcopenia and physical frailty can be perceived as related to the same target organ (i.e., skeletal muscle) and it may be possible to combine them into a unique definition. The biological background of such a close relationship needs to be explored and clarified as it can potentially provide novel and pivotal insights for the assessment and treatment of these conditions in old age. The aim of this paper is to indicate and discuss possible biological markers to be considered in the framing of physical frailty and sarcopenia.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.