ArticleRMD open2017
Preliminary validation of the Knee Inflammation MRI Scoring System (KIMRISS) for grading bone marrow lesions in osteoarthritis of the knee: data from the Osteoarthritis Initiative.
Article in RMD open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- Validation of a new topographic classification of bone marrow lesions in the knee: the six-letter system.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021Trial
- Localizing Knee Pain via Explainable Bayesian Generative Models and Counterfactual MRI: Data from the Osteoarthritis Initiative.Journal of imaging informatics in medicine · 2026Article
- Validation of an AI-based automated Knee Inflammation MRI Scoring System for assessing bone marrow lesions.EULAR rheumatology open · 2026Article
- Advances in the pathology and treatment of osteoarthritis.Journal of advanced research · 2025Review
- Pain Phenotype in Knee Osteoarthritis: Implications for Mechanism-Based Therapy.Orthopaedic surgery · 2025Review
- Enhancing knee MRI bone marrow lesion detection with artificial intelligence: An external validation study.Research in diagnostic and interventional imaging · 2025Article
- Imaging of osteoarthritis-related bone marrow lesions in clinical trials.Osteoarthritis imaging · 2025Article
- Bone marrow lesions in osteoarthritis: biomarker or treatment target? A narrative review.Skeletal radiology · 2025Review
- Bone marrow lesions in osteoarthritis: Characterising genetic and histological changes to understand disease pathophysiology.Osteoarthritis and cartilage open · 2024Review
- Progression of Bone Marrow Lesions and the Development of Knee Osteoarthritis: Osteoarthritis Initiative Data.Radiology · 2024Article
- Comparative validation of the knee inflammation MRI scoring system and the MRI osteoarthritis knee score for semi-quantitative assessment of bone marrow lesions and synovitis-effusion in osteoarthritis: an international multi-reader exercise.Therapeutic advances in musculoskeletal disease · 2023Article
- Efficacy and safety of culture-expanded, mesenchymal stem/stromal cells for the treatment of knee osteoarthritis: a systematic review protocol.Journal of orthopaedic surgery and research · 2019Article
- Imaging of osteoarthritis-recent research developments and future perspective.The British journal of radiology · 2018Review
- Immune Contributions to Osteoarthritis.Current osteoporosis reports · 2017Review
- Innate Immune Responses and Osteoarthritis.Current rheumatology reports · 2017Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveBone marrow lesions (BML) are an MRI feature of osteoarthritis (OA) offering a potential target for therapy. We developed the Knee Inflammation MRI Scoring System (KIMRISS) to semiquantitatively score BML with high sensitivity to small changes, and compared feasibility, reliability and responsiveness versus the established MRI Osteoarthritis Knee Score (MOAKS).
methodsKIMRISS incorporates a web-based graphic overlay to facilitate detailed regional BML scoring. Observers scored BML by MOAKS and KIMRISS on sagittal fluid-sensitive sequences. Exercise 1 focused on interobserver reliability in Osteoarthritis Initiative observational data, with 4 readers (two experienced/two new to KIMRISS) scoring BML in 80 patients (baseline/1 year). Exercise 2 focused on responsiveness in an open-label trial of adalimumab, with 2 experienced readers scoring BML in 16 patients (baseline/12 weeks).
resultsScoring time was similar for KIMRISS and MOAKS. Interobserver reliability of KIMRISS was equivalent to MOAKS for BML status (ICC=0.84 vs 0.79), but consistently better than MOAKS for change in BML: Exercise 1 (ICC 0.82 vs 0.53), Exercise 2 (ICC 0.90 vs 0.32), and in new readers (0.87-0.92 vs 0.32-0.51). KIMRISS BML was more responsive than MOAKS BML: post-treatment BML improvement in Exercise 2 reached statistical significance for KIMRISS (SRM -0.69, p=0.015), but not MOAKS (SRM -0.12, p=0.625). KIMRISS BML also more strongly correlated to WOMAC scores than MOAKS BML (r=0.80 vs 0.58, p<0.05).
conclusionsKIMRISS BML scoring was highly feasible, and was more reliable for assessment of change and more responsive to change than MOAKS BML for expert and new readers.
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