Evidence map›Paper›PMID 28123757›Full record

ArticleOpen heart

Lower coronary plaque burden in patients with HIV presenting with acute coronary syndrome.

E J O'Dwyer, P Bhamra-Ariza, S Rao, S Emmanuel, A Carr, C J Holloway

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open heart. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Coronary Artery Disease in Patients with HIV Infection: An Update.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2021
    Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Epidemiology of ischemic heart disease in HIV.Current opinion in HIV and AIDS · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

E J O'DwyerSt. Vincent's Hospital Darlinghurst and the University of New South Wales, Sydney, New South Wales, Australia; University of New South Wales, Sydney, New South Wales, Australia; Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.
P Bhamra-ArizaSt. Vincent's Hospital Darlinghurst and the University of New South Wales, Sydney, New South Wales, Australia; Frimley Health NHS Foundation, Surrey, UK.
S RaoSt. Vincent's Hospital Darlinghurst and the University of New South Wales, Sydney, New South Wales, Australia; Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.
S EmmanuelSt. Vincent's Hospital Darlinghurst and the University of New South Wales, Sydney, New South Wales, Australia; University of Notre Dame, Sydney, New South Wales, Australia.
A CarrSt. Vincent's Hospital Darlinghurst and the University of New South Wales, Sydney, New South Wales, Australia; University of New South Wales, Sydney, New South Wales, Australia.
C J HollowaySt. Vincent's Hospital Darlinghurst and the University of New South Wales, Sydney, New South Wales, Australia; University of New South Wales, Sydney, New South Wales, Australia; Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia; Frimley Health NHS Foundation, Surrey, UK.
St Vincent's Hospital Sydney · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTreated HIV infection is associated with a higher incidence of coronary artery disease and myocardial infarction, although the mechanisms remain unclear. We sought to characterise the burden of coronary artery disease in men with HIV using retrospective data from invasive coronary angiograms in patients presenting with acute coronary syndrome (ACS).

methodsDemographic and coronary angiographic data were obtained from 160 men with ST elevation myocardial infarction, non-STEMI or high-risk chest pain; 73 HIV-infected cases and 87 age-matched controls. The burden of coronary disease was calculated using the Gensini Angiographic Scoring System by 2 independent cardiologists blinded to HIV status.

resultsThe 2 groups were matched for age, sex and cardiac event subtype and there was no difference in rates of smoking or cholesterol levels. Compared with control participants, patients with HIV had higher usage of antihypertensives (46 (63%) vs 30 (35%), p<0.001) and statins (47 (64%) vs 29 (33%), p<0.001). There was no difference in plaque distribution between both groups; however, the Gensini score was 42% lower in cases with HIV than in controls (p<0.03). C reactive protein was higher in cases with HIV (13.4±15.4 vs 3.7±3.6).

conclusionsMen with HIV presenting with ACS paradoxically had a lower burden of coronary plaque than matched controls, despite more aggressive risk factor management, suggesting that plaque vulnerability, rather than total burden of atherosclerosis, may be important in the pathophysiology of coronary artery disease in men with HIV.

Indexed as

CORONARY ARTERY DISEASE

Identifiers

PMID28123757
PMCPMC5237750
OpenAlexW2567715974

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.