ArticleBMJ open respiratory research2017
Timing of hypertonic saline and airway clearance techniques in adults with cystic fibrosis during pulmonary exacerbation: pilot data from a randomised crossover study.
Article in BMJ open respiratory research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01753869 (Timing of Hypertonic Saline Inhalation Relative to Airways Clearance in Cystic Fibrosis), which is not on this map. Cited by 10 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Timing of Hypertonic Saline Inhalation Relative to Airways Clearance in Cystic Fibrosis
Who cites it
10 citing papers in PubMed, 6 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Nebulised hypertonic saline for cystic fibrosis.The Cochrane database of systematic reviews · 2023Pooled it
- Active cycle of breathing technique for cystic fibrosis.The Cochrane database of systematic reviews · 2023Pooled it
- Oscillating devices for airway clearance in people with cystic fibrosis.The Cochrane database of systematic reviews · 2020Pooled it
- Timing of hypertonic saline inhalation for cystic fibrosis.The Cochrane database of systematic reviews · 2020Pooled it
- Nebulised hypertonic saline for cystic fibrosis.The Cochrane database of systematic reviews · 2018Pooled it
- Oscillating devices for airway clearance in people with cystic fibrosis.The Cochrane database of systematic reviews · 2017Pooled it
- MetaNeb Versus Usual Care During Exacerbations of Cystic Fibrosis: An RCT.Respirology (Carlton, Vic.) · 2025Trial
- Randomised cross-over trial evaluating the short-term effects of non-invasive ventilation as an adjunct to airway clearance techniques in adults with cystic fibrosis.BMJ open respiratory research · 2019Trial
- Personalising airway clearance in chronic suppurative lung diseases: a scoping review.ERJ open research · 2023Article
- Methods Used to Evaluate the Immediate Effects of Airway Clearance Techniques in Adults with Cystic Fibrosis: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStreamlining the timing of treatments in cystic fibrosis (CF) is important to optimise adherence while ensuring efficacy. The optimal timing of treatment with hypertonic saline (HTS) and airway clearance techniques (ACT) is unknown.
objectivesThis study hypothesised that HTS before ACT would be more effective than HTS during ACT as measured by Lung Clearance Index (LCI).
methodsAdults with CF providing written informed consent were randomised to a crossover trial of HTS before ACT or HTS during ACT on consecutive days. ACT treatment consisted of Acapella Duet. Patients completed LCI and spirometry at baseline and 90 min post treatment. Mean difference (MD) and 95% CIs were reported.
results13 subjects completed the study (mean (SD) age 33 (12) years, forced expiratory volume in 1second % (FEV
conclusionsIn this pilot study, HTS before ACT was no more effective than HTS during ACT as measured by LCI. TRIAL REGISTRATION NUMBER: NCT01753869; Pre-results.
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