Evidence map›Paper›PMID 28123720›Full record

ArticleBiomedical reports2017

Vitamin D improves immune function in immunosuppressant mice induced by glucocorticoid.

Zongye Wang, Ying Wang, Bingxin Xu, Junli Liu, Ye Ren, Zhuojie Dai, Di Cui, Xiaoming Su, Shaoyan Si, Shu Jun Song

Open access · bronzeAbstract read
In one paragraph

Article in Biomedical reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Frontiers in veterinary science · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Vitamin D levels and oxidative stress markers in patients hospitalized with COVID-19.Redox report : communications in free radical research · 2021
    Article
  7. Article
  8. Article
  9. Antioxidants (Basel, Switzerland) · 2020
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zongye WangDepartment of Therapeutic Radiology and Oncology, The 306th Hospital of PLA, ChaoYang, Beijing 100101, P.R. China.
Ying WangDepartment of Therapeutic Radiology and Oncology, The 306th Hospital of PLA, ChaoYang, Beijing 100101, P.R. China.
Bingxin XuCenter for Special Medicine and Experimental Research, The 306th Hospital of PLA, ChaoYang, Beijing 100101, P.R. China.
Junli LiuCenter for Special Medicine and Experimental Research, The 306th Hospital of PLA, ChaoYang, Beijing 100101, P.R. China.
Ye RenDepartment of Therapeutic Radiology and Oncology, The 306th Hospital of PLA, ChaoYang, Beijing 100101, P.R. China.
Zhuojie DaiDepartment of Therapeutic Radiology and Oncology, The 306th Hospital of PLA, ChaoYang, Beijing 100101, P.R. China.
Di CuiDepartment of Therapeutic Radiology and Oncology, The 306th Hospital of PLA, ChaoYang, Beijing 100101, P.R. China.
Xiaoming SuDepartment of Therapeutic Radiology and Oncology, The 306th Hospital of PLA, ChaoYang, Beijing 100101, P.R. China.
Shaoyan SiCenter for Special Medicine and Experimental Research, The 306th Hospital of PLA, ChaoYang, Beijing 100101, P.R. China.
Shu Jun SongCenter for Special Medicine and Experimental Research, The 306th Hospital of PLA, ChaoYang, Beijing 100101, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin D is an essential fat-soluble vitamin with multiple functions. Vitamin D receptor has been shown to be expressed in several types of immune cells suggesting vitamin D may have immune regulatory roles. Vitamin D insufficiency has been suggested to increase the risk of autoimmune diseases. However, little is known regarding its immunomodulatory effects in the condition of immune suppression. The aim of the present study was to investigate the regulatory effects of vitamin D on immune function in immunosuppressant mice. An immunosuppressant mouse model was induced by intraperitoneal injection with glucocorticiod for 3 days. Immunosuppressant mice were intragastrically administered with 1,25-dihydroxy-vitamin D3 [1,25(OH)

Indexed as

immunityinterleukin-2T lymphocytesvitamin D

Identifiers

PMID28123720
PMCPMC5244759
OpenAlexW2551026632

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.