Evidence map›Paper›PMID 28123462›Full record

ArticleExperimental and therapeutic medicine2017

Detection of auto antibodies and transplantation of cultured autologous melanocytes for the treatment of vitiligo.

Mei-Cai Zhu, Hong-Yu Ma, Zhi Zhan, Cheng-Gang Liu, Wei Luo, Guang Zhao

Open access · diamondAbstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Current Status of Cell-Based Therapies for Vitiligo.International journal of molecular sciences · 2023
    Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mei-Cai ZhuCenter of Clinical Laboratory, Air Force General Hospital, Beijing 100036, P.R. China.
Hong-Yu MaCenter of Clinical Laboratory, Air Force General Hospital, Beijing 100036, P.R. China.
Zhi ZhanCenter of Clinical Laboratory, Air Force General Hospital, Beijing 100036, P.R. China.
Cheng-Gang LiuCenter of Clinical Laboratory, Air Force General Hospital, Beijing 100036, P.R. China.
Wei LuoDepartment of Dermatology, Air Force General Hospital, Beijing 100036, P.R. China.
Guang ZhaoDepartment of Dermatology, Air Force General Hospital, Beijing 100036, P.R. China.
Air Force General Hospital PLA · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the present study was to establish an immunofluorescence method of antibody detection to identify melanocytes in the serum of vitiligo patients. Furthermore, we aimed to establish a method for the culture and proliferation of autologous pure melanocytes and to observe the effect of their transplantation for the treatment of vitiligo. Suspension of epidermal cells with melanocytes was performed using trypsin digestion of normal epiderm from eyelid operation and melanocytes were selectively cultured and proliferated in serum-free M2 medium. FITC-labeled rabbit anti-human antibody was used to detect the relative fluorescence intensity of the melanocytes. After identification with immunological and biological examinations, the melanocytes were transplanted to depigmented areas of vitiligo. Repigmentation was observed continuously. The results indicated that melanocytes could be selectively proliferated in the medium. Subsequently, pure melanocytes without contamination of fibroblast and keratinocyte were harvested. A total of 34 patients suffering vitiligo for between 3 months and 20 years with depigmented area (between 4 cm

Indexed as

antibody against melanocytesautologous transplantationimmunofluorescencemelanocyte culturevitiligo

Identifiers

PMID28123462
PMCPMC5244765
OpenAlexW2557603033

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.