Evidence map›Paper›PMID 28123461›Full record

ArticleExperimental and therapeutic medicine2017

Involvement of NADPH oxidase in high-dose phenolic acid-induced pro-oxidant activity on rat mesenteric venules.

Wen-Yuan Du, Ying Xiao, Jian-Jing Yao, Zhe Hao, Yu-Bin Zhao

Open access · diamondAbstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Frontiers in pharmacology · 2024
    Review
  3. Article
  4. Article
  5. Review
  6. Antiproliferative Effects of Ferulic, Coumaric, and Caffeic Acids in HepG2 Cells byAdvances in pharmacological and pharmaceutical sciences · 2022
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Wen-Yuan DuMedical and Electronic Experimental Center, The Traditional Chinese Medicine Hospital of Shijiazhuang Affiliated to Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050051, P.R. China.
Ying XiaoSchool of Chemical Engineering, Shijiazhuang University, Shijiazhuang, Hebei 050035, P.R. China.
Jian-Jing YaoMedical and Electronic Experimental Center, The Traditional Chinese Medicine Hospital of Shijiazhuang Affiliated to Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050051, P.R. China.
Zhe HaoThe Third Hospital of Shijiazhuang, Shijiazhuang, Hebei 050011, P.R. China.
Yu-Bin ZhaoMedical and Electronic Experimental Center, The Traditional Chinese Medicine Hospital of Shijiazhuang Affiliated to Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050051, P.R. China; The Third Hospital of Shijiazhuang, Shijiazhuang, Hebei 050011, P.R. China.
Hebei University of Chinese Medicine · CNShijiazhuang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present study, we investigated the potential role of phenolic acids in initiating oxidative damage to microvascular endothelial cells and the underlying mechanism mediating the pro-oxidant action. Male Wistar rats received high doses of phenolic acid [caffeic acid (CA), salvianolic acid B (SAB), chlorogenic acid (ChA) or ferulic acid (FA)]. The creation of reactive oxygen species in mesenteric microcirculation endothelial cells and adherent leukocytes along with venules were assessed using intravital microscopy. The expression levels of NADPH oxidase subunits (Nox4 and p22

Indexed as

drug safetymesenteric microcirculationNADPH oxidasephenolic acidreactive oxygen species

Identifiers

PMID28123461
PMCPMC5244796
OpenAlexW2556710347

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.