Evidence map›Paper›PMID 28123369›Full record

ArticleFrontiers in physiology2016

Differential Bone Loss in Mouse Models of Colon Cancer Cachexia.

Andrea Bonetto, Joshua K Kays, Valorie A Parker, Ryan R Matthews, Rafael Barreto, Melissa J Puppa, Kyung S Kang, James A Carson, Theresa A Guise, Khalid S Mohammad and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 71 citations in OpenAlex.

  1. Review
  2. Article
  3. Cancer cachexia: molecular basis and therapeutic advances.Signal transduction and targeted therapy · 2026
    Review
  4. Article
  5. Physical Activity, Exerkines, and Their Role in Cancer Cachexia.International journal of molecular sciences · 2025
    Review
  6. Review
  7. Article
  8. Review
  9. Exploring heterogeneity: a dive into preclinical models of cancer cachexia.American journal of physiology. Cell physiology · 2024
    Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Role of the Osteocyte in Musculoskeletal Disease.Current osteoporosis reports · 2023
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Andrea BonettoDepartment of Surgery, Indiana University School of MedicineIndianapolis, IN, USA; Department of Otolaryngology, Head and Neck Surgery, Indiana University School of MedicineIndianapolis, IN, USA; Simon Cancer Center, Indiana University School of MedicineIndianapolis, IN, USA; Indiana University-Purdue University at Indianapolis, Center for Cachexia Research, Innovation and Therapy, Indiana University School of MedicineIndianapolis, IN, USA.
Joshua K KaysDepartment of Surgery, Indiana University School of Medicine Indianapolis, IN, USA.
Valorie A ParkerDepartment of Surgery, Indiana University School of Medicine Indianapolis, IN, USA.
Ryan R MatthewsDepartment of Surgery, Indiana University School of Medicine Indianapolis, IN, USA.
Rafael BarretoDepartment of Surgery, Indiana University School of Medicine Indianapolis, IN, USA.
Melissa J PuppaDepartment of Exercise Science, University of South Carolina Columbia, SC, USA.
Kyung S KangDepartment of Anatomy and Cell Biology, Indiana University School of Medicine Indianapolis, IN, USA.
James A CarsonDepartment of Exercise Science, University of South Carolina Columbia, SC, USA.
Theresa A GuiseSimon Cancer Center, Indiana University School of MedicineIndianapolis, IN, USA; Department of Medicine, Indiana University School of MedicineIndianapolis, IN, USA.
Khalid S MohammadSimon Cancer Center, Indiana University School of MedicineIndianapolis, IN, USA; Department of Medicine, Indiana University School of MedicineIndianapolis, IN, USA.
Alexander G RoblingDepartment of Anatomy and Cell Biology, Indiana University School of Medicine Indianapolis, IN, USA.
Marion E CouchDepartment of Otolaryngology, Head and Neck Surgery, Indiana University School of MedicineIndianapolis, IN, USA; Indiana University-Purdue University at Indianapolis, Center for Cachexia Research, Innovation and Therapy, Indiana University School of MedicineIndianapolis, IN, USA.
Leonidas G KoniarisDepartment of Surgery, Indiana University School of MedicineIndianapolis, IN, USA; Simon Cancer Center, Indiana University School of MedicineIndianapolis, IN, USA; Indiana University-Purdue University at Indianapolis, Center for Cachexia Research, Innovation and Therapy, Indiana University School of MedicineIndianapolis, IN, USA.
Teresa A ZimmersDepartment of Surgery, Indiana University School of MedicineIndianapolis, IN, USA; Department of Otolaryngology, Head and Neck Surgery, Indiana University School of MedicineIndianapolis, IN, USA; Simon Cancer Center, Indiana University School of MedicineIndianapolis, IN, USA; Indiana University-Purdue University at Indianapolis, Center for Cachexia Research, Innovation and Therapy, Indiana University School of MedicineIndianapolis, IN, USA; Department of Anatomy and Cell Biology, Indiana University School of MedicineIndianapolis, IN, USA.
Indiana University – Purdue University Indianapolis · USIndiana University School of MedicineUniversity of South Carolina · USIndiana University Health · US

Funding

Manipulation of STAT3 Signaling for Muscle Preservation in Cancer CachexiaR01CA122596 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ZIMMERS, TERESA A · 2010 to 2015
$1.6M
PQB3: Mechanisms & Targeting of Sonic Hedgehog Signaling in Muscle Wasting of Cancer CachexiaR01CA194593 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI ZIMMERS, TERESA A · 2015 to 2018
$1.4M
NCI NIH HHS R01 CA122596NCI NIH HHS R01 CA194593
6 · The paper itself

Abstract

Cachexia is a distinctive feature of colorectal cancer associated with body weight loss and progressive muscle wasting. Several mechanisms responsible for muscle and fat wasting have been identified, however it is not known whether the physiologic and molecular crosstalk between muscle and bone tissue may also contribute to the cachectic phenotype in cancer patients. The purpose of this study was to clarify whether tumor growth associates with bone loss using several experimental models of colorectal cancer cachexia, namely C26, HT-29, and Apc

Indexed as

bone losscachexiacolon cancermuscle wastingosteopeniaosteoporosis

Identifiers

PMID28123369
PMCPMC5225588
OpenAlexW2573888447

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.