Evidence map›Paper›PMID 28123368›Full record

ArticleFrontiers in pharmacology2016

Achieving Acetylcholine Receptor Clustering in Tissue-Engineered Skeletal Muscle Constructs

John B Scott, Catherine L Ward, Benjamin T Corona, Michael R Deschenes, Benjamin S Harrison, Justin M Saul, George J Christ

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

John B ScottWake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston-SalemNC, USA; Virginia Tech - Wake Forest University School of Biomedical Engineering and Sciences, Wake Forest University Biomedical Engineering, Winston-SalemNC, USA.
Catherine L WardWake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston-SalemNC, USA; US Army Institute for Surgical Research, San AntonioTX, USA.
Benjamin T CoronaWake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston-SalemNC, USA; US Army Institute for Surgical Research, San AntonioTX, USA.
Michael R DeschenesDepartment of Neuroscience, College of William and Mary, Williamsburg VA, USA.
Benjamin S HarrisonWake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston-SalemNC, USA; Virginia Tech - Wake Forest University School of Biomedical Engineering and Sciences, Wake Forest University Biomedical Engineering, Winston-SalemNC, USA.
Justin M SaulDepartment of Chemical, Paper and Biomedical Engineering, Miami University, Oxford OH, USA.
George J ChristWake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston-SalemNC, USA; Department of Biomedical Engineering and Department of Orthopaedic Surgery, University of Virginia, CharlottesvilleVA, USA.
United States Army Institute of Surgical Research · USVirginia Tech - Wake Forest University School of Biomedical Engineering & Sciences · USForest Institute · USMiami University · USWilliam & Mary · US

Funding

Keratin hydrogel matrix for tunable growth factor delivery in bone regenerationR01AR061391 · NIAMS · MIAMI UNIVERSITY OXFORD · PI SAUL, JUSTIN · 2012 to 2015
$1.4M
NIAMS NIH HHS R01 AR061391
6 · The paper itself

Abstract

Volumetric muscle loss (VML) can result from trauma, infection, congenital anomalies, or surgery, and produce permanent functional and cosmetic deficits. There are no effective treatment options for VML injuries, and recent advances toward development of muscle constructs lack the ability to achieve innervation necessary for long-term function. We sought to develop a proof-of-concept biomaterial construct that could achieve acetylcholine receptor (AChR) clustering on muscle-derived cells (MDCs)

Indexed as

bioreactordrug deliveryfibrinmicrospheresregenerative medicinetissue engineering

Identifiers

PMID28123368
PMCPMC5225105
OpenAlexW2569794166

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.