Evidence map›Paper›PMID 28123296›Full record

ArticleInternational journal of nanomedicine2017

Reduced bacterial growth and increased osteoblast proliferation on titanium with a nanophase TiO

Garima Bhardwaj, Thomas J Webster

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Ni and TiOEnvironmental science and pollution research international · 2021
    Article
  6. Biomedical Applications of TiOInternational journal of nanomedicine · 2020
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Garima BhardwajDepartment of Chemical Engineering, Northeastern University, Boston, MA, USA.
Thomas J WebsterDepartment of Chemical Engineering, Northeastern University, Boston, MA, USA.
Northeastern University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe attachment and initial growth of bacteria on an implant surface dictates the progression of infection. Treatment often requires aggressive antibiotic use, which does not always work. To overcome the difficulties faced in systemic and local antibiotic delivery, scientists have forayed into using alternative techniques, which includes implant surface modifications that prevent initial bacterial adhesion, foreign body formation, and may offer a controlled inflammatory response.

objectiveThe current study focused on using electrophoretic deposition to treat titanium with a nanophase titanium dioxide surface texture to reduce bacterial adhesion and growth. Two distinct nanotopographies were analyzed, Ti-160, an antimicrobial surface designed to greatly reduce bacterial colonization, and Ti-120, an antimicrobial surface with a topography that upregulates osteoblast activity while reducing bacterial colonization; the number following Ti in the nomenclature represents the atomic force microscopy root-mean-square roughness value in nanometers.

resultsThere was a 95.6% reduction in

conclusionCompared to untreated surfaces, Ti-160-treated titanium surfaces demonstrated a statistically significant 1 log reduction in

Indexed as

BacteriaBacterial AdhesionCell ProliferationColony Count, MicrobialEscherichia coliHumansNanoparticlesOsteoblastsPseudomonas aeruginosaStaphylococcus aureusSurface PropertiesTitaniumTitaniumtitanium dioxideelectrophoretic depositioninfectionnanotopographytitanium dioxide

Identifiers

PMID28123296
PMCPMC5229166
OpenAlexW2570352744

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.