ArticleInternational journal of nanomedicine2017
Platelet-functionalized three-dimensional poly-ε-caprolactone fibrous scaffold prepared using centrifugal spinning for delivery of growth factors.
Article in International journal of nanomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Activated Platelet-Rich Plasma Fibrin Scaffolds Enhance Axonal Regeneration and Functional Recovery Following Spinal Cord Injury.Annals of biomedical engineering · 2026Article
- Enhancing abdominal wall healing using an oriented polycaprolactone microfibrous scaffold prepared using the fiber drawing method: A rabbit model study.Hernia : the journal of hernias and abdominal wall surgery · 2026Article
- Biomimetic Nanoparticles for Bone Regeneration: Construction Strategies and Therapeutic Mechanisms.International journal of nanomedicine · 2026Review
- Fiber Technology in Drug Delivery and Pharmaceuticals.Current drug delivery · 2025Review
- Investigation of Signals and Transcription Factors for The Generation of Female Germ-Like Cells.Cell journal · 2022Article
- Advances in the development of hemostatic biomaterials for medical application.Biomaterials research · 2021Review
- The Effect of the Controlled Release of Platelet Lysate from PVA Nanomats on Keratinocytes, Endothelial Cells and Fibroblasts.Nanomaterials (Basel, Switzerland) · 2021Article
- Hydrogel Containing Anti-CD44-Labeled Microparticles, Guide Bone Tissue Formation in Osteochondral Defects in Rabbits.Nanomaterials (Basel, Switzerland) · 2020Article
- Comparative Analysis of Mesenchymal Stem Cell Cultivation in Fetal Calf Serum, Human Serum, and Platelet Lysate in 2D and 3D Systems.Frontiers in bioengineering and biotechnology · 2020Article
- Osteoinductive 3D scaffolds prepared by blend centrifugal spinning for long-term delivery of osteogenic supplements.RSC advances · 2018Article
- Designing of PLA scaffolds for bone tissue replacement fabricated by ordinary commercial 3D printer.Journal of biological engineering · 2017Article
Corrections and comments
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Authors and funding
9 authors.
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Abstract
Bone and cartilage are tissues of a three-dimensional (3D) nature. Therefore, scaffolds for their regeneration should support cell infiltration and growth in all 3 dimensions. To fulfill such a requirement, the materials should possess large, open pores. Centrifugal spinning is a simple method for producing 3D fibrous scaffolds with large and interconnected pores. However, the process of bone regeneration is rather complex and requires additional stimulation by active molecules. In the current study, we introduced a simple composite scaffold based on platelet adhesion to poly-ε-caprolactone 3D fibers. Platelets were used as a natural source of growth factors and cytokines active in the tissue repair process. By immobilization in the fibrous scaffolds, their bioavailability was prolonged. The biological evaluation of the proposed system in the MG-63 model showed improved metabolic activity, proliferation and alkaline phosphatase activity in comparison to nonfunctionalized fibrous scaffold. In addition, the response of cells was dose dependent with improved biocompatibility with increasing platelet concentration. The results demonstrated the suitability of the system for bone tissue.
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