Evidence map›Paper›PMID 28123183›Full record

ArticleGenes and immunity2017

Epistatic effect of TLR-1, -6 and -10 polymorphisms on organic dust-mediated cytokine response.

L M Smith, L A Weissenburger-Moser, A J Heires, K L Bailey, D J Romberger, T D LeVan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Respiratory Diseases Associated With Organic Dust Exposure.The journal of allergy and clinical immunology. In practice · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

L M SmithDepartment of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
L A Weissenburger-MoserDepartment of Epidemiology, University of Nebraska Medical Center, Omaha, NE, USA.
A J HeiresDepartment of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
K L BaileyDepartment of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
D J RombergerDepartment of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
T D LeVanDepartment of Epidemiology, University of Nebraska Medical Center, Omaha, NE, USA.
University of Nebraska Medical Center · USVA Nebraska Western Iowa Health Care System · US

Funding

Mucociliary clearance in agingR01AG053553 · NIA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BAILEY, KRISTINA L · 2016 to 2020
$1.5M
Molecular Genetics of Pathogen Recognition Receptors in COPDI01CX000434 · VA · OMAHA VA MEDICAL CENTER · PI LEVAN, TRICIA D · 2011 to 2014
–
CSRD VA I01 CX000434NIA NIH HHS R01 AG053553NIOSH CDC HHS U54 OH010162
6 · The paper itself

Abstract

Exposure to organic dust from agricultural environments is associated with inflammatory respiratory conditions. The putative causal agents in organic dust include viral, microbial and fungal components, which are recognized by the family of Toll-like receptors (TLRs) and drive host innate and adaptive responses. Our aim in this study was to determine whether responsiveness to organic dust among agricultural workers was dependent on polymorphisms in the TLR10-TLR1-TLR6 gene cluster. We stimulated whole blood from 509 agricultural workers with organic dust, triacyl lipopeptide N-palmitoyl-S-dipalmitoylglyceryl Cys-Ser-(Lys)

Indexed as

DustEpistasis, GeneticAgedAnimal HusbandryAnimalsFemaleHumansImmunity, InnateInterleukin-6LipopeptidesMaleMiddle AgedOccupational ExposurePeptidoglycanPolymorphism, GeneticPolymorphism, Single NucleotideDustIL6 protein, humanInterleukin-6LipopeptidesPam(3)CSK(4) peptidePeptidoglycanTLR10 protein, humanTLR6 protein, humanToll-Like Receptor 1Toll-Like Receptor 10Toll-Like Receptor 6Tumor Necrosis Factor-alpha

Identifiers

PMID28123183
PMCPMC5407948
OpenAlexW2581902607

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.