ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Cortical Representation of Interaural Time Difference Is Impaired by Deafness in Development: Evidence from Children with Early Long-term Access to Sound through Bilateral Cochlear Implants Provided Simultaneously.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 33 citations in OpenAlex.
- Binaural sensitivity and processing of envelope-based interaural difference cues by bilateral cochlear implant users with perilingual and postlingual onset of deafness.The Journal of the Acoustical Society of America · 2026Article
- Article
- Ear-Specific Hemispheric Asymmetry in Unilateral Deafness Revealed by Auditory Cortical Activity.Frontiers in neuroscience · 2021Article
- Evaluating the Impact of Age, Acoustic Exposure, and Electrical Stimulation on Binaural Sensitivity in Adult Bilateral Cochlear Implant Patients.Brain sciences · 2020Article
- Bimodal Benefits for Lexical Tone Recognition: An Investigation on Mandarin-speaking Preschoolers with a Cochlear Implant and a Contralateral Hearing Aid.Brain sciences · 2020Article
- Limiting asymmetric hearing improves benefits of bilateral hearing in children using cochlear implants.Scientific reports · 2018Article
- Cortical hemispheric asymmetries are present at young ages and further develop into adolescence.Human brain mapping · 2018Article
- Delayed access to bilateral input alters cortical organization in children with asymmetric hearing.NeuroImage. Clinical · 2018Article
- Cortical organization restored by cochlear implantation in young children with single sided deafness.Scientific reports · 2017Article
- Challenges of Cochlear Implant Use for Spatial Hearing in Children and Adolescents With Asymmetric Hearing Including Single Sided Deafness.Trends in hearingArticle
- Children With Bilateral Cochlear Implants Show Emerging Spatial Hearing of Stationary and Moving Sound.Trends in hearingArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Accurate use of interaural time differences (ITDs) for spatial hearing may require access to bilateral auditory input during sensitive periods in human development. Providing bilateral cochlear implants (CIs) simultaneously promotes symmetrical development of bilateral auditory pathways but does not support normal ITD sensitivity. Thus, although binaural interactions are established by bilateral CIs in the auditory brainstem, potential deficits in cortical processing of ITDs remain. Cortical ITD processing in children with simultaneous bilateral CIs and normal hearing with similar time-in-sound was explored in the present study. Cortical activity evoked by bilateral stimuli with varying ITDs (0, ±0.4, ±1 ms) was recorded using multichannel electroencephalography. Source analyses indicated dominant activity in the right auditory cortex in both groups but limited ITD processing in children with bilateral CIs. In normal-hearing children, adult-like processing patterns were found underlying the immature P1 (∼100 ms) response peak with reduced activity in the auditory cortex ipsilateral to the leading ITD. Further, the left cortex showed a stronger preference than the right cortex for stimuli leading from the contralateral hemifield. By contrast, children with CIs demonstrated reduced ITD-related changes in both auditory cortices. Decreased parieto-occipital activity, possibly involved in spatial processing, was also revealed in children with CIs. Thus, simultaneous bilateral implantation in young children maintains right cortical dominance during binaural processing but does not fully overcome effects of deafness using present CI devices. Protection of bilateral pathways through simultaneous implantation might be capitalized for ITD processing with signal processing advances, which more consistently represent binaural timing cues.
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