ArticleScience translational medicine2017
Abnormal neurogenesis and cortical growth in congenital heart disease.
Article in Science translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 2 of them syntheses that pooled it.
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Who cites it
71 citing papers in PubMed, 2 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- Causal inference between neurodevelopmental disorders and brain structure among individuals with congenital heart disease: Insights from meta-analysis and Mendelian randomization.Italian journal of pediatrics · 2026Pooled it
- Meta-regression of sulcal patterns, clinical and environmental factors on neurodevelopmental outcomes in participants with multiple CHD types.Cerebral cortex (New York, N.Y. : 1991) · 2024Pooled it
- Brain volumes in congenital heart disease from childhood to adulthood: A pooled neuroimaging study.Neuroimage. Reports · 2026Article
- Cytoarchitecture of neurogenic niche and neuroblast clusters in the postnatal microminipig brain.Stem cell reports · 2026Article
- Perinatal brain developmental transition revealed by transcriptomic and proteomic analyses of Bama miniature pigs.Nature communications · 2026Article
- Germ-free piglets display variable neuroinflammatory-like perturbations in prefrontal cortical microglia.bioRxiv : the preprint server for biology · 2026Article
- Preoperative Hemodynamics and Brain Injury in Transposition of the Great Arteries.JACC. Advances · 2026Article
- The Sooner, the Better: Neuroprotective Strategies in Fetuses With Congenital Heart Disease.Prenatal diagnosis · 2026Review
- Cortical morphology and cognitive impairments in adolescents with complex congenital heart disease.Brain communications · 2026Article
- Neurodevelopment in congenital heart disease: a review of antenatal mechanisms and therapeutic potentials.Pediatric research · 2025Review
- Effect of Fetal Brain Oxygenation and Volume on Brain Maturation and Neurodevelopmental Outcomes in Congenital Heart Disease.Radiology · 2025Article
- An expanded subventricular zone supports postnatal cortical interneuron migration in gyrencephalic brains.Nature neuroscience · 2025Article
- Patterns of phosphorylated tau accumulation in a spectrum of acquired and developmental brain lesions associated with refractory epilepsy.Epilepsia · 2025Article
- Cortical scaling of the neonatal brain in typical and altered development.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Associations between preoperative cerebral white matter microstructural changes and neurodevelopmental deficits in CHD infants: a diffusion tensor imaging study.Italian journal of pediatrics · 2025Article
- Foetal cortical expansion is associated with neurodevelopmental outcome at 2-years in congenital heart disease: a longitudinal follow-up study.EBioMedicine · 2025Article
- Outer radial glia promotes white matter regeneration after neonatal brain injury.Cell reports. Medicine · 2025Article
- Structural Covariance Networks in the Fetal Brain Reveal Altered Neurodevelopment for Specific Subtypes of Congenital Heart Disease.Journal of the American Heart Association · 2024Article
- The cumulative impact of clinical risk on brain networks and associations with executive function impairments in adolescents with congenital heart disease.Human brain mapping · 2024Article
- Validation of a Paralimbic-Related Subcortical Brain Dysmaturation MRI Score in Infants with Congenital Heart Disease.Journal of clinical medicine · 2024Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Long-term neurological deficits due to immature cortical development are emerging as a major challenge in congenital heart disease (CHD). However, cellular mechanisms underlying dysregulation of perinatal corticogenesis in CHD remain elusive. The subventricular zone (SVZ) represents the largest postnatal niche of neural stem/progenitor cells (NSPCs). We show that the piglet SVZ resembles its human counterpart and displays robust postnatal neurogenesis. We present evidence that SVZ NSPCs migrate to the frontal cortex and differentiate into interneurons in a region-specific manner. Hypoxic exposure of the gyrencephalic piglet brain recapitulates CHD-induced impaired cortical development. Hypoxia reduces proliferation and neurogenesis in the SVZ, which is accompanied by reduced cortical growth. We demonstrate a similar reduction in neuroblasts within the SVZ of human infants born with CHD. Our findings demonstrate that SVZ NSPCs contribute to perinatal corticogenesis and suggest that restoration of SVZ NSPCs' neurogenic potential is a candidate therapeutic target for improving cortical growth in CHD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.