ArticleProceedings of the National Academy of Sciences of the United States of America2017
Flow-assisted assembly of nanostructured protein microfibers.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- A Review on Micromixers, Microdroplet Generators and Their Integration.Micromachines · 2026Review
- Hydro-Torsional Compaction for Scalable Production of Aramid Nanofiber Threads with Densely Assembled Double-Helical Nanostructures.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Clog-free all-aqueous microfluidic fabrication of hydrogel microfibers governed by a universal scaling law.Lab on a chip · 2026Article
- Enzyme-Triggered Formation of Tensegrity Structures for Mechanospatial Manipulation of Hydrogels.Gels (Basel, Switzerland) · 2025Article
- Tuning Alignment, Strength, and Toughness in Functional Cellulose:Helux Filaments: A Molecular Trade-Off.Biomacromolecules · 2025Article
- Hydrogels with prestressed tensegrity structures.Nature communications · 2025Article
- Confinement-Induced Self-Assembly of Protein Nanofibrils Probed by Microfocus X-ray Scattering.The journal of physical chemistry. B · 2025Article
- Post-spin Stretch Improves Mechanical Properties, Reduces Necking, and Reverts Effects of Aging in Biomimetic Artificial Spider Silk Fibers.ACS applied polymer materials · 2024Article
- Strategies for Making High-Performance Artificial Spider Silk Fibers.Advanced functional materials · 2024Review
- From Fundamental Amyloid Protein Self-Assembly to Development of Bioplastics.Biomacromolecules · 2024Review
- The role of flow in the self-assembly of dragline spider silk proteins.Biophysical journal · 2023Article
- Nordic Crops as Alternatives to Soy-An Overview of Nutritional, Sensory, and Functional Properties.Foods (Basel, Switzerland) · 2023Review
- Food protein-derived amyloids do not accelerate amyloid β aggregation.Scientific reports · 2023Article
- Deep learning applied to analyze patterns from evaporated droplets of Viscum album extracts.Scientific reports · 2022Article
- Nanofibril Alignment during Assembly Revealed by an X-ray Scattering-Based Digital Twin.ACS nano · 2022Article
- Review
- Deconstruction and Reassembly of Renewable Polymers and Biocolloids into Next Generation Structured Materials.Chemical reviews · 2021Review
- Structural characterisation of amyloid-like fibrils formed by an amyloidogenic peptide segment of β-lactoglobulin.RSC advances · 2021Article
- From Protein Building Blocks to Functional Materials.ACS nano · 2021Review
- Bioactive hierarchical silk fibers created by bioinspired self-assembly.Nature communications · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Some of the most remarkable materials in nature are made from proteins. The properties of these materials are closely connected to the hierarchical assembly of the protein building blocks. In this perspective, amyloid-like protein nanofibrils (PNFs) have emerged as a promising foundation for the synthesis of novel bio-based materials for a variety of applications. Whereas recent advances have revealed the molecular structure of PNFs, the mechanisms associated with fibril-fibril interactions and their assembly into macroscale structures remain largely unexplored. Here, we show that whey PNFs can be assembled into microfibers using a flow-focusing approach and without the addition of plasticizers or cross-linkers. Microfocus small-angle X-ray scattering allows us to monitor the fibril orientation in the microchannel and compare the assembly processes of PNFs of distinct morphologies. We find that the strongest fiber is obtained with a sufficient balance between ordered nanostructure and fibril entanglement. The results provide insights in the behavior of protein nanostructures under laminar flow conditions and their assembly mechanism into hierarchical macroscopic structures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.