ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Noisy Spiking in Visual Area V2 of Amblyopic Monkeys.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Comparative Effects of Monocular and Stereopsis Training on Visual Acuity and Stereoacuity in Children With Amblyopia.Investigative ophthalmology & visual science · 2026Article
- Spatiotemporal Dynamics of Binocular Interaction in Anisometropic Amblyopia Revealed by Classification Image.Investigative ophthalmology & visual science · 2026Article
- Differential Effects of Balanced and Imbalanced Binocular Stimulation on Visual Cortex Responses in Amblyopic Children.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Eye-hand coordination during visually-guided reaching in children with monocular deprivation amblyopia.Vision research · 2025Article
- Amblyopia and the whole child.Progress in retinal and eye research · 2023Review
- Contour integration deficits at high spatial frequencies in children treated for anisometropic amblyopia.Frontiers in neuroscience · 2023Article
- Binocular visual experience drives the maturation of response variability and reliability in the visual cortex.iScience · 2022Article
- Rethinking amblyopia 2020.Vision research · 2020Review
- Attention in visually typical and amblyopic children.Journal of vision · 2020Article
- Two Patterns of Interocular Delay Revealed by Spontaneous Motion-in-Depth Pulfrich Phenomenon in Amblyopes with Stereopsis.Investigative ophthalmology & visual science · 2020Article
- Optimal Stereoacuity Reveals More Than Critical Time in Patients With Intermittent Exotropia.Frontiers in neuroscience · 2020Article
- Altered functional interactions between neurons in primary visual cortex of macaque monkeys with experimental amblyopia.Journal of neurophysiology · 2019Article
- The Importance of the Interaction Between Ocular Motor Function and Vision During Human Infancy.Annual review of vision science · 2019Review
- Amblyopia Affects the ON Visual Pathway More than the OFF.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Impaired Fellow Eye Motion Perception and Abnormal Binocular Function.Investigative ophthalmology & visual science · 2019Article
- Spiking Noise and Information Density of Neurons in Visual Area V2 of Infant Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Long-Range Interocular Suppression in Adults with Strabismic Amblyopia: A Pilot fMRI Study.Vision (Basel, Switzerland) · 2019Article
- Long-term histological changes in the macaque primary visual cortex and the lateral geniculate nucleus after monocular deprivation produced by early restricted retinal lesions and diffuser induced form deprivation.The Journal of comparative neurology · 2018Article
- Endogenous attention improves perception in amblyopic macaques.Journal of vision · 2018Article
- Observations on the relationship between anisometropia, amblyopia and strabismus.Vision research · 2017Review
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6 authors.
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Abstract
Interocular decorrelation of input signals in developing visual cortex can cause impaired binocular vision and amblyopia. Although increased intrinsic noise is thought to be responsible for a range of perceptual deficits in amblyopic humans, the neural basis for the elevated perceptual noise in amblyopic primates is not known. Here, we tested the idea that perceptual noise is linked to the neuronal spiking noise (variability) resulting from developmental alterations in cortical circuitry. To assess spiking noise, we analyzed the contrast-dependent dynamics of spike counts and spiking irregularity by calculating the square of the coefficient of variation in interspike intervals (CV SIGNIFICANCE STATEMENT: Amblyopia is a common developmental vision disorder in humans. Despite the extensive animal studies on how amblyopia emerges, we know surprisingly little about the neural basis of amblyopia in humans and nonhuman primates. Although the vision of amblyopic humans is often described as being noisy by perceptual and modeling studies, the exact nature or origin of this elevated perceptual noise is not known. We show that elevated and noisy spontaneous activity and contrast-dependent noisy spiking (spiking irregularity and trial-to-trial fluctuations in spiking) in neurons of visual area V2 could limit the visual performance of amblyopic primates. Moreover, we discovered that the noisy spiking is linked to a high level of binocular suppression in visual cortex during development.
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