ArticleJournal of neurophysiology2017
Spontaneous dynamics of neural networks in deep layers of prefrontal cortex.
Article in Journal of neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
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- Hippocampal-prefrontal functional neural networks in a rat model of fragile X syndrome are poorly organized with limited resiliency.Scientific reports · 2025Article
- Neural Oscillations in the Somatosensory and Motor Cortex Distinguish Dexmedetomidine-Induced Anesthesia and Sleep in Rats.CNS neuroscience & therapeutics · 2025Article
- Recurrent activity propagates through labile ensembles in macaque dorsolateral prefrontal microcircuits.Current biology : CB · 2025Article
- Enhanced electrophysiological recordings in acute brain slices, spheroids, and organoids using 3D high-density multielectrode arrays.PloS one · 2025Article
- A multiparametric calcium signal screening platform using iPSC-derived cortical neural spheroids.SLAS discovery : advancing life sciences R & D · 2022Article
- Experience-dependent plasticity modulates ongoing activity in the antennal lobe and enhances odor representations.Cell reports · 2021Article
- Preventing adolescent synaptic pruning in mouse prelimbic cortex via local knockdown of α4βδ GABAScientific reports · 2021Article
- Understanding ethanol's acute effects on medial prefrontal cortex neural activity using state-space approaches.Neuropharmacology · 2021Review
- Electrophysiological Correlates of Shyness Affected by Facial Attractiveness.Frontiers in psychology · 2021Article
- Behavioral inhibition and EEG delta-beta correlation in early childhood: Comparing a between-subjects and within-subjects approach.Biological psychology · 2020Article
- Synchronized activation of striatal direct and indirect pathways underlies the behavior in unilateral dopamine-depleted mice.The European journal of neuroscience · 2019Article
- Alterations in Schizophrenia-Associated Genes Can Lead to Increased Power in Delta Oscillations.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
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Authors and funding
3 authors.
Funding
Abstract
Cortical systems maintain and process information through the sustained activation of recurrent local networks of neurons. Layer 5 is known to have a major role in generating the recurrent activation associated with these functions, but relatively little is known about its intrinsic dynamics at the mesoscopic level of large numbers of neighboring neurons. Using calcium imaging, we measured the spontaneous activity of networks of deep-layer medial prefrontal cortical neurons in an acute slice model. Inferring the simultaneous activity of tens of neighboring neurons, we found that while the majority showed only sporadic activity, a subset of neurons engaged in sustained delta frequency rhythmic activity. Spontaneous activity under baseline conditions was weakly correlated between pairs of neurons, and rhythmic neurons showed little coherence in their oscillations. However, we consistently observed brief bouts of highly synchronous activity that must be attributed to network activity. NMDA-mediated stimulation enhanced rhythmicity, synchrony, and correlation within these local networks. These results characterize spontaneous prefrontal activity at a previously unexplored spatiotemporal scale and suggest that medial prefrontal cortex can act as an intrinsic generator of delta oscillations.
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