Evidence map›Paper›PMID 28122985›Full record

ArticleJournal of virology2017

BCA2/Rabring7 Interferes with HIV-1 Proviral Transcription by Enhancing the SUMOylation of IκBα.

Marta Colomer-Lluch, Ruth Serra-Moreno

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. The RING finger protein family in health and disease.Signal transduction and targeted therapy · 2022
    Review
  9. Cancer-Associated Dysregulation of Sumo Regulators: Proteases and Ligases.International journal of molecular sciences · 2022
    Review
  10. Review
  11. Article
  12. Residues TRetrovirology · 2021
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Barriers for HIV Cure: The Latent Reservoir.AIDS research and human retroviruses · 2018
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Marta Colomer-LluchDepartment of Biological Sciences, College of Arts and Sciences, Texas Tech University, Lubbock, Texas, USA.
Ruth Serra-MorenoDepartment of Biological Sciences, College of Arts and Sciences, Texas Tech University, Lubbock, Texas, USA ruth.serra-moreno@ttu.edu.
Texas Tech University · US

Funding

Characterization of the antiviral activity of BCA2R21AI106400 · NIAID · TEXAS TECH UNIVERSITY · PI SERRA MORENO, RUTH · 2014 to 2015
$398k
NIAID NIH HHS R21 AI106400
6 · The paper itself

Abstract

BCA2/Rabring7 is a BST2 cofactor that promotes the lysosomal degradation of trapped HIV-1 virions but also functions as a BST2-independent anti-HIV factor by targeting Gag for lysosomal degradation. Since many antiviral factors regulate the NF-κB innate signaling pathway, we investigated whether BCA2 is also connected to this proinflammatory cascade. Here, we show for the first time that

Indexed as

Transcription, GeneticVirus ReplicationCD4-Positive T-LymphocytesHIV-1NF-KappaB Inhibitor alphaProvirusesSumoylationUbiquitin-Protein LigasesNF-KappaB Inhibitor alphaRNF115 protein, humanUbiquitin-Protein Ligaseshost-pathogen interactionshuman immunodeficiency virusinnate immunityNF-κBvirology

Identifiers

PMID28122985
PMCPMC5375697
OpenAlexW2582507337

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.