Evidence map›Paper›PMID 28122978›Full record

ArticleJournal of virology2017

Conserved Interaction of Lentiviral Vif Molecules with HIV-1 Gag and Differential Effects of Species-Specific Vif on Virus Production.

Wenwen Zheng, Limian Ling, Zhaolong Li, Hong Wang, Yajuan Rui, Wenying Gao, Shaohua Wang, Xing Su, Wei Wei, Xiao-Fang Yu

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Current and Future Therapeutic Strategies for Lentiviral Eradication from Macrophage Reservoirs.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2019
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Wenwen ZhengInstitute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin Province, China.
Limian LingDepartment of Colorectal and Anal Surgery, First Hospital of Jilin University, Changchun, Jilin Province, China.
Zhaolong LiInstitute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin Province, China.
Hong WangSchool of Life Science, Tianjin University, Tianjin, China.
Yajuan RuiInstitute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin Province, China.
Wenying GaoInstitute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin Province, China.
Shaohua WangInstitute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin Province, China.
Xing SuInstitute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin Province, China.
Wei WeiInstitute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin Province, China wwei6@jlu.edu.cn xyu2@jhu.edu.
Xiao-Fang YuInstitute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin Province, China wwei6@jlu.edu.cn xyu2@jhu.edu.
First Hospital of Jilin University · CNJilin University · CNJohns Hopkins University · USTianjin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The virion infectivity factor (Vif) open reading frame is conserved among most lentiviruses. Vif molecules contribute to viral replication by inactivating host antiviral factors, the APOBEC3 cytidine deaminases. However, various species of lentiviral Vif proteins have evolved different strategies for overcoming host APOBEC3. Whether different species of lentiviral Vif proteins still preserve certain common features has not been reported. Here, we show for the first time that diverse lentiviral Vif molecules maintain the ability to interact with the human immunodeficiency virus type 1 (HIV-1) Gag precursor (Pr55

Indexed as

Virus ReplicationAmino Acid SequenceConserved Sequencegag Gene Products, Human Immunodeficiency VirusHEK293 CellsHIV-1HumansImmunodeficiency Virus, BovineModels, MolecularProtein Interaction Domains and MotifsProtein Processing, Post-TranslationalSpecies Specificityvif Gene Products, Human Immunodeficiency Virusgag Gene Products, Human Immunodeficiency Virusvif Gene Products, Human Immunodeficiency VirusBIV VifHIV-1HIV-1 Gag precursorviral infectivity factor

Identifiers

PMID28122978
PMCPMC5355596
OpenAlexW2582883355

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.