Evidence map›Paper›PMID 28122947›Full record

ArticleG3 (Bethesda, Md.)2017

Functional Analysis of Kinases and Transcription Factors in

Ji-Young Youn, Helena Friesen, Alex N Nguyen Ba, Wendy Liang, Vincent Messier, Mike J Cox, Alan M Moses, Brenda Andrews

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. IdentifyingG3 (Bethesda, Md.) · 2019
    Article
  13. Article
  14. Mapping a diversity of genetic interactions in yeast.Current opinion in systems biology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ji-Young YounDepartment of Molecular Genetics, University of Toronto, Ontario M5S 3E1, Canada.ORCID 0000-0001-6799-5709
Helena FriesenTerrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Ontario M5S 3E1, Canada.ORCID 0000-0001-8925-7440
Alex N Nguyen BaDepartment of Cell and Systems Biology, University of Toronto, Ontario M5S 3B2, Canada.ORCID 0000-0003-1357-6386
Wendy LiangTerrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Ontario M5S 3E1, Canada.ORCID 0000-0001-7454-8456
Vincent MessierTerrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Ontario M5S 3E1, Canada.ORCID 0000-0003-0476-5425
Mike J CoxDepartment of Molecular Genetics, University of Toronto, Ontario M5S 3E1, Canada.
Alan M MosesDepartment of Cell and Systems Biology, University of Toronto, Ontario M5S 3B2, Canada.
Brenda AndrewsDepartment of Molecular Genetics, University of Toronto, Ontario M5S 3E1, Canada brenda.andrews@utoronto.ca.ORCID 0000-0001-6427-6493
University of Toronto · CA

Funding

CIHR FDN-143264CIHR MOP-119579CIHR MT-11206
6 · The paper itself

Abstract

Kinases and transcription factors (TFs) are key modulators of important signaling pathways and their activities underlie the proper function of many basic cellular processes such as cell division, differentiation, and development. Changes in kinase and TF dosage are often associated with disease, yet a systematic assessment of the cellular phenotypes caused by the combined perturbation of kinases and TFs has not been undertaken. We used a reverse-genetics approach to study the phenotypic consequences of kinase and TF overexpression (OE) in the budding yeast,

Indexed as

Gene LibraryAllelesGene DosageGene Expression Regulation, FungalGreen Fluorescent ProteinsMutationProtein KinasesProtein Processing, Post-TranslationalSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription FactorsGreen Fluorescent ProteinsProtein KinasesSaccharomyces cerevisiae ProteinsTranscription Factorsgenetic interactionsgenetic networkskinasetranscription factoryeast genetics

Identifiers

PMID28122947
PMCPMC5345721
OpenAlexW2580545209

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.