Observational studyDiabetes care2017
Nondiabetic Glucometabolic Status and Progression of Aortic Stiffness: The Whitehall II Study.
Observational study in Diabetes care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Trial
- Association between METS-VF and hypertension in U.S.: a cross-sectional analysis of NHANES data.Scientific reports · 2026Article
- Association between glycometabolic indicators and risk of early vascular aging and their predictive value.Frontiers in endocrinology · 2026Article
- Noninvasive Assessment of Arterial Wall and Soluble ST2 in Patients with Type 2 Diabetes and Coronary Artery Disease.International journal of molecular sciences · 2025Article
- Association between metabolic score for insulin resistance (METS-IR) and hypertension: a cross-sectional study based on NHANES 2007-2018.Lipids in health and disease · 2025Article
- Glycated Hemoglobin and Cardiovascular Disease in Patients Without Diabetes.Journal of clinical medicine · 2024Review
- Correlation between the triglyceride-glucose index and arterial stiffness in Japanese individuals with normoglycaemia: a cross-sectional study.BMC endocrine disorders · 2024Article
- Associations of Glucometabolic Indices with Aortic Stiffness in Patients Undergoing Peritoneal Dialysis with and without Diabetes Mellitus.International journal of molecular sciences · 2023Article
- Metabolic and Vascular Risk Factor Variability Over 25 Years Relates to Midlife Brain Volume and Cognition.Journal of Alzheimer's disease : JAD · 2023Article
- Association of METS-IR with incident hypertension in non-overweight adults based on a cohort study in Northeastern China.European journal of public health · 2022Article
- Arterial Stiffness and HbA1c: Association Mediated by Insulin Resistance in Hispanic Adults.International journal of environmental research and public health · 2022Article
- Association of Nondiabetic Glucometabolic Status and Aortic Stiffness in Community Hypertension Patients.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Association of Insulin Resistance with Vascular Ageing in a General Caucasian Population: An EVA Study.Journal of clinical medicine · 2021Article
- Advanced glycation end-products, measured as skin autofluorescence, associate with vascular stiffness in diabetic, pre-diabetic and normoglycemic individuals: a cross-sectional study.Cardiovascular diabetology · 2021Article
- Differences in longitudinal associations of cardiovascular risk factors with arterial stiffness and pressure wave reflection in middle-aged Japanese men.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Observational
- Association of aortic stiffness with cognitive decline: Whitehall II longitudinal cohort study.European journal of epidemiology · 2020Article
- Association of insulin resistance, from mid-life to late-life, with aortic stiffness in late-life: the Atherosclerosis Risk in Communities Study.Cardiovascular diabetology · 2020Article
- Visit-to-Visit Fasting Glucose Variability in Young Adulthood and Hippocampal Integrity and Volume at Midlife.Diabetes care · 2019Article
- Determinants of Vascular Age: An Epidemiological Perspective.Clinical chemistry · 2019Review
- Association Between Glucose Metabolism And Vascular Aging In Chinese Adults: A Cross-Sectional Analysis In The Tianning Cohort Study.Clinical interventions in aging · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
objectiveAortic stiffness is an important predictor of future morbidity and mortality. Diabetes is associated with increased aortic stiffness, but the importance of nondiabetic glucometabolic status for accelerated aortic stiffening is unclear. We tested the hypothesis that adverse glucometabolic status is associated with accelerated aortic stiffening in individuals without diabetes, independently of known risk factors for arterial stiffening. RESEARCH DESIGN AND
methodsGlucometabolic status and other cardiovascular risk factors were assessed at baseline in 2008-09, and carotid femoral pulse wave velocity (cfPWV) at baseline and follow-up in 2012-13, in 4,386 participants without diabetes of the Whitehall II Study.
resultsThe mean age of the cohort at cfPWV baseline was 60 years, and 74% were male. cfPWV increased from (mean ± SE) 8.30 ± 0.03 to 8.98 ± 0.04 m/s during 4 years of follow-up. At baseline, cfPWV was associated with fasting and 2-h postload glucose, HbA
conclusionsHbA
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.