Evidence map›Paper›PMID 28122650›Full record

SynthesisPsychological medicine2017

Job strain as a risk factor for clinical depression: systematic review and meta-analysis with additional individual participant data.

I E H Madsen, S T Nyberg, L L Magnusson Hanson, J E Ferrie, K Ahola, L Alfredsson, G D Batty, J B Bjorner, M Borritz, H Burr and 32 more

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Psychological medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 205 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
205citing papers in PubMed, 12 pooled it
76.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

205 citing papers in PubMed, 12 syntheses or guidelines pooled it, 451 citations in OpenAlex.

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  3. Psychosocial Occupational Exposures and Mental Illness.Deutsches Arzteblatt international · 2022
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  16. Evaluating the Impact of the Prime Time Sister CirclesJournal of general internal medicine · 2023
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  18. Factors Associated with Work-Related Burnout among Corporate Employees Amidst COVID-19 Pandemic.International journal of environmental research and public health · 2022
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145 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors at 20 institutions in 7 countries.

I E H MadsenNational Research Centre for the Working Environment,DK-2100 Copenhagen Ø,Denmark.
S T NybergFinnish Institute of Occupational Health,FI-00250 Helsinki,Finland.
L L Magnusson HansonStress Research Institute, Stockholm University,SE-106 91 Stockholm,Sweden.
J E FerrieDepartment of Epidemiology and Public Health,University College London,London WC1E 6BT,UK.
K AholaFinnish Institute of Occupational Health,FI-00250 Helsinki,Finland.
L AlfredssonInstitute of Environmental Medicine,Karolinska Institutet,SE-171 77 Stockholm,Sweden.
G D BattyDepartment of Epidemiology and Public Health,University College London,London WC1E 6BT,UK.
J B BjornerNational Research Centre for the Working Environment,DK-2100 Copenhagen Ø,Denmark.
M BorritzDepartment of Occupational and Environmental Medicine,Bispebjerg University Hospital,DK-2400 Copenhagen,Denmark.
H BurrFederal Institute for Occupational Safety and Health (BAuA),D-10317 Berlin,Germany.
J-F ChastangINSERM, U1085, Research Institute for Environmental and Occupational Health (IRSET), Epidemiology in Occupational Health and Ergonomics (ESTER) Team, F-49000, Angers,France.
R de GraafNetherlands Institute of Mental Health and Addiction,3521 VS Utrecht,The Netherlands.
N DraganoDepartment of Medical Sociology,University of Düsseldorf,40225 Düsseldorf,Germany.
M HamerDepartment of Epidemiology and Public Health,University College London,London WC1E 6BT,UK.
M JokelaInstitute of Behavioral Sciences,University of Helsinki,FI-00014 Helsinki,Finland.
A KnutssonDepartment of Health Sciences,Mid Sweden University,SE-851 70 Sundsvall,Sweden.
M KoskenvuoDepartment of Public Health,University of Helsinki,FI-00014 Helsinki,Finland.
A KoskinenFinnish Institute of Occupational Health,FI-00250 Helsinki,Finland.
C LeineweberStress Research Institute, Stockholm University,SE-106 91 Stockholm,Sweden.
I NiedhammerINSERM, U1085, Research Institute for Environmental and Occupational Health (IRSET), Epidemiology in Occupational Health and Ergonomics (ESTER) Team, F-49000, Angers,France.
M L NielsenUnit of Social Medicine,Frederiksberg University Hospital,DK-2000 Copenhagen,Denmark.
M NordinStress Research Institute, Stockholm University,SE-106 91 Stockholm,Sweden.
T OksanenFinnish Institute of Occupational Health,FI-00250 Helsinki,Finland.
J H PejtersenThe Danish National Centre for Social Research,DK-1052 Copenhagen,Denmark.
J PenttiFinnish Institute of Occupational Health,FI-00250 Helsinki,Finland.
I PlaisierThe Netherlands Institute for Social Research,2515 XP The Hague,The Netherlands.
P SaloFinnish Institute of Occupational Health,FI-00250 Helsinki,Finland.
A Singh-ManouxDepartment of Epidemiology and Public Health,University College London,London WC1E 6BT,UK.
S SuominenFolkhälsan Research Center,FI-00290 Helsinki,Finland.
M Ten HaveNetherlands Institute of Mental Health and Addiction,3521 VS Utrecht,The Netherlands.
T TheorellStress Research Institute, Stockholm University,SE-106 91 Stockholm,Sweden.
S Toppinen-TannerFinnish Institute of Occupational Health,FI-00250 Helsinki,Finland.
J VahteraFinnish Institute of Occupational Health,FI-00250 Helsinki,Finland.
A VäänänenFinnish Institute of Occupational Health,FI-00250 Helsinki,Finland.
P J M WesterholmOccupational and Environmental Medicine,Uppsala University,SE-751 85 Uppsala,Sweden.
H WesterlundStress Research Institute, Stockholm University,SE-106 91 Stockholm,Sweden.
E I FranssonStress Research Institute, Stockholm University,SE-106 91 Stockholm,Sweden.
K HeikkiläFinnish Institute of Occupational Health,FI-00250 Helsinki,Finland.
M VirtanenFinnish Institute of Occupational Health,FI-00250 Helsinki,Finland.
R RuguliesNational Research Centre for the Working Environment,DK-2100 Copenhagen Ø,Denmark.
M KivimäkiFinnish Institute of Occupational Health,FI-00250 Helsinki,Finland.
IPD-Work Consortium
Finnish Institute of Occupational Health · FIStockholm University · SEInstitut de Recherche en Santé, Environnement et Travail · FRNational Research Centre for the Working Environment · DKTrimbos Institute · NLUniversity of Helsinki · FIBispebjerg Hospital · DKDanish National Centre for Social Research · DKFederal Institute for Occupational Safety and Health · DEFrederiksberg Hospital · DKHeinrich Heine University Düsseldorf · DEInserm · FRJönköping University · SEKarolinska Institutet · SELondon School of Hygiene & Tropical Medicine · GBLoughborough University · GBMid Sweden University · SENetherlands Institute for Social Research · NLNordic School of Public Health · SEUniversity College London · GB

Funding

Medical Research Council MR/K013351/1Medical Research Council MR/K026992/1
6 · The paper itself

Abstract

backgroundAdverse psychosocial working environments characterized by job strain (the combination of high demands and low control at work) are associated with an increased risk of depressive symptoms among employees, but evidence on clinically diagnosed depression is scarce. We examined job strain as a risk factor for clinical depression.

methodWe identified published cohort studies from a systematic literature search in PubMed and PsycNET and obtained 14 cohort studies with unpublished individual-level data from the Individual-Participant-Data Meta-analysis in Working Populations (IPD-Work) Consortium. Summary estimates of the association were obtained using random-effects models. Individual-level data analyses were based on a pre-published study protocol.

resultsWe included six published studies with a total of 27 461 individuals and 914 incident cases of clinical depression. From unpublished datasets we included 120 221 individuals and 982 first episodes of hospital-treated clinical depression. Job strain was associated with an increased risk of clinical depression in both published [relative risk (RR) = 1.77, 95% confidence interval (CI) 1.47-2.13] and unpublished datasets (RR = 1.27, 95% CI 1.04-1.55). Further individual participant analyses showed a similar association across sociodemographic subgroups and after excluding individuals with baseline somatic disease. The association was unchanged when excluding individuals with baseline depressive symptoms (RR = 1.25, 95% CI 0.94-1.65), but attenuated on adjustment for a continuous depressive symptoms score (RR = 1.03, 95% CI 0.81-1.32).

conclusionsJob strain may precipitate clinical depression among employees. Future intervention studies should test whether job strain is a modifiable risk factor for depression.

Indexed as

Depressive DisorderHumansOccupational StressObservational studiesoccupational healthwork stress

Identifiers

PMID28122650
PMCPMC5471831
OpenAlexW2579902429

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.