ArticleBMC biology2017
Search strategy is regulated by somatostatin signaling and deep brain photoreceptors in zebrafish.
Article in BMC biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Behavioral algorithms of ontogenetic switching in larval and juvenile zebrafish phototaxis.iScience · 2026Article
- Protocol for using the multi-cellular analysis toolbox in ImageJ for single-cell calcium imaging analysis.STAR protocols · 2026Article
- Neural circuits for decision-making based on pineal photoreception in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Neurotrophic Modulation Restores Motor and Developmental Defects in Zebrafish Models of ints11 Deficiency.Journal of neurochemistry · 2026Article
- A multicellular analysis calcium imaging toolbox for ImageJ.Cell reports methods · 2026Article
- Linking brain and behavior states in Zebrafish Larvae locomotion using hidden Markov models.PLoS computational biology · 2026Article
- Article
- Lighting and circadian cues shape locomotor strategies for balance and navigation in larval zebrafish.bioRxiv : the preprint server for biology · 2025Article
- The rx3 Gene Contributes to the Evolution of Eye Loss in the Cavefish Astyanax mexicanus.Evolution & development · 2025Article
- A detailed quantification of larval zebrafish behavioral repertoire uncovers principles of hunting behavior.iScience · 2025Article
- High throughput machine learning pipeline to characterize larval zebrafish motor behavior.PloS one · 2025Article
- Uncovering multiscale structure in the variability of larval zebrafish navigation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Zebrafish Dark-Dependent Behavior Requires Phototransduction by the Pineal Gland.Journal of pineal research · 2024Article
- A large-scale CRISPR screen reveals context-specific genetic regulation of retinal ganglion cell regeneration.Development (Cambridge, England) · 2024Article
- Light wavelength modulates search behavior performance in zebrafish.Scientific reports · 2024Article
- Article
- Key HPI axis receptors facilitate light adaptive behavior in larval zebrafish.Scientific reports · 2024Article
- Transcriptional control of visual neural circuit development by GS homeobox 1.PLoS genetics · 2024Article
- Context-dependent hyperactivity inFrontiers in molecular neuroscience · 2024Article
- Optimizing assays of zebrafish larvae swimming performance for drug discovery.Expert opinion on drug discovery · 2023Review
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Authors and funding
4 authors.
Funding
Abstract
backgroundAnimals use sensory cues to efficiently locate resources, but when sensory information is insufficient, they may rely on internally coded search strategies. Despite the importance of search behavior, there is limited understanding of the underlying neural mechanisms in vertebrates.
resultsHere, we report that loss of illumination initiates sophisticated light-search behavior in larval zebrafish. Using three-dimensional tracking, we show that at the onset of darkness larvae swim in a helical trajectory that is spatially restricted in the horizontal plane, before gradually transitioning to an outward movement profile. Local and outward swim patterns display characteristic features of area-restricted and roaming search strategies, differentially enhancing phototaxis to nearby and remote sources of light. Retinal signaling is only required to initiate area-restricted search, implying that photoreceptors within the brain drive the transition to the roaming search state. Supporting this, orthopediaA mutant larvae manifest impaired transition to roaming search, a phenotype which is recapitulated by loss of the non-visual opsin opn4a and somatostatin signaling.
conclusionThese findings define distinct neuronal pathways for area-restricted and roaming search behaviors and clarify how internal drives promote goal-directed activity.
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