Evidence map›Paper›PMID 28122354›Full record

ArticleOncotarget2017

CX3CL1: a potential chemokine widely involved in the process spinal metastases.

WangMi Liu, Chong Bian, Yun Liang, Libo Jiang, Chen Qian, Jian Dong

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

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  11. Clinical significance of expression level of CX3CL1-CX3CR1 axis in bone metastasis of lung cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

WangMi LiuDepartment of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Chong BianDepartment of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Yun LiangDepartment of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Libo JiangDepartment of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Chen QianDepartment of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Jian DongDepartment of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
The First Affiliated Hospital, Sun Yat-sen University · CNFudan University · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of our study was to investigate the general mechanism of spinal metastases from five different primary cancers: lung cancer, breast cancer, liver cancer, prostate cancer, and kidney cancer.

resultsFrom microarray analysis and validation by real-time polymerase chain reaction, CX3C chemokine ligand 1 (CX3CL1) appeared to be a potential chemokine widely involved in the process of spinal metastases. Further studies revealed that, compared with normal controls, serum samples from patients with spinal metastases from the lung (P < 0.01), kidney (P < 0.05) and prostate (P < 0.05) contained significantly higher levels of CX3CL1, whereas those from patients with spinal metastases from the liver and breast had a tendency to contain higher levels of CX3CL1 but without significance. Immunohistochemical staining for the expression of CX3C chemokine receptor 1 (CX3CR1), the receptor for CX3CL1, in all spinal metastases samples showed negative staining. MATERIALS AND

methodsCancellous bone in the spine from patients with and without spinal metastases was collected for mRNA microarray study, and then differentially expressed mRNAs related to chemokines were further confirmed by real-time polymerase chain reaction. Enzyme linked immunosorbent assay was used to detect the serum level of the selected chemokines and immunohistochemical staining was used to detect the expression level of corresponding receptors in tumor.

conclusionsOur present study showed that CX3CL1 is associated with the process of spinal metastases from different primary cancers.

Indexed as

Biomarkers, TumorChemokine CX3CL1HumansImmunoenzyme TechniquesNeoplasmsReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSpinal NeoplasmsTumor Cells, CulturedBiomarkers, TumorChemokine CX3CL1CX3CL1 protein, humanRNA, MessengerCX3CL1metastasisspine

Identifiers

PMID28122354
PMCPMC5362480
OpenAlexW2575654520

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.