ArticleCell reports2017
Evolutionary Remodeling of Bacterial Motility Checkpoint Control.
Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Article
- Adaptation to a host-associated lifestyle is associated with convergent loss of flagella-related genes in Pseudomonadota.BMC genomics · 2026Article
- Motile and non-motile Listeria species adopt distinct ecological and evolutionary strategies to achieve broad geographic ranges across soil ecosystems.The ISME journal · 2026Article
- Investigating the effects of soil microstructures on bacterial growth via microfluidic channels and an agent-based model.Scientific reports · 2025Article
- Control of flagellar gene expression by a chemotaxis receptor-like regulator in pathogenic Escherichia coli.The EMBO journal · 2025Article
- Bacterial Minicell-Based Biohybrid Sub-micron Swimmers for Targeted Cargo Delivery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Navigating bacterial motility through chemotaxis: from molecular mechanisms to physiological perspectives.Folia microbiologica · 2025Review
- Experimental evolution partially restores functionality of bacterial chemotaxis network with reduced number of components.PLoS genetics · 2025Article
- Motile and Chemotactic Minicells and Minicell-Driven Biohybrids Engineered for Active Cargo Delivery.ACS applied materials & interfaces · 2025Article
- Role of a single MCP in evolutionary adaptation ofApplied and environmental microbiology · 2025Article
- Nongenetic adaptation by collective migration.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Physics of swimming and its fitness cost determine strategies of bacterial investment in flagellar motility.Nature communications · 2025Article
- Hybrid Exb/Mot stators require substitutions distant from the chimeric pore to power flagellar rotation.Journal of bacteriology · 2024Article
- Revisiting the evolution of bow-tie architecture in signaling networks.NPJ systems biology and applications · 2024Article
- Direct measurement of dynamic attractant gradients reveals breakdown of the Patlak-Keller-Segel chemotaxis model.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Deep mutational scanning reveals the molecular determinants of RNA polymerase-mediated adaptation and tradeoffs.Nature communications · 2023Article
- Direct measurement of dynamic attractant gradients reveals breakdown of the Patlak-Keller-Segel chemotaxis model.bioRxiv : the preprint server for biology · 2023Article
- Chromosomal Position of Ribosomal Protein Genes Affects Long-Term Evolution of Vibrio cholerae.mBio · 2023Article
- Impact of direct physical association and motility on fitness of a synthetic interkingdom microbial community.The ISME journal · 2023Article
- Genome-wide transcriptional response of Escherichia coli O157:H7 to light-emitting diodes with various wavelengths.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Regulatory networks play a central role in the relationship between genotype and phenotype in all organisms. However, the mechanisms that underpin the evolutionary plasticity of these networks remain poorly understood. Here, we used experimental selection for enhanced bacterial motility in a porous environment to explore the adaptability of one of the most complex networks known in bacteria. We found that the resulting phenotypic changes are mediated by adaptive mutations in several functionally different proteins, including multiple components of the flagellar motor. Nevertheless, this evolutionary adaptation could be explained by a single mechanism, namely remodeling of the checkpoint regulating flagellar gene expression. Supported by computer simulations, our findings suggest that the specific "bow-tie" topology of the checkpoint facilitates evolutionary tuning of the cost-benefit trade-off between motility and growth. We propose that bow-tie regulatory motifs, which are widespread in cellular networks, play a general role in evolutionary adaptation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.