ArticleCell reports2017
Germ Cell-less Promotes Centrosome Segregation to Induce Germ Cell Formation.
Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- Caspar modulates primordial germ cell fate both in an Oskar-dependent and Oskar-independent manner.Biology open · 2025Article
- Visualization of the Cytoskeleton in Fixed Drosophila Embryos.Current protocols · 2025Article
- Review
- Article
- Regulation of early spermatogenesis in the giant prawn Macrobrachium rosenbergii by a GCL homolog†.Biology of reproduction · 2024Article
- Reshaping the Syncytial Drosophila Embryo with Cortical Actin Networks: Four Main Steps of Early Development.Results and problems in cell differentiation · 2024Review
- Germline/soma distinction ineLife · 2023Article
- Orb-dependent polyadenylation contributes to PLP expression and centrosome scaffold assembly.Development (Cambridge, England) · 2022Article
- Preformation and epigenesis converge to specify primordial germ cell fate in the early Drosophila embryo.PLoS genetics · 2022Article
- Antagonism betweeneLife · 2021Article
- Drosophila pericentrin-like protein promotes the formation of primordial germ cells.Genesis (New York, N.Y. : 2000) · 2020Article
- Transcriptomic and functional analysis of the oosome, a unique form of germ plasm in the wasp Nasonia vitripennis.BMC biology · 2019Article
- Germ granules in Drosophila.Traffic (Copenhagen, Denmark) · 2019Review
- Coordination of Embryogenesis by the Centrosome in Drosophila melanogaster.Results and problems in cell differentiation · 2019Review
- Transcriptional quiescence in primordial germ cells.Critical reviews in biochemistry and molecular biology · 2018Review
- DistinctDevelopment (Cambridge, England) · 2018Article
- Review
- Tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo.Nature communications · 2018Review
- Double abdomen in a short-germ insect: Zygotic control of axis formation revealed in the beetleProceedings of the National Academy of Sciences of the United States of America · 2018Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
The primordial germ cells (PGCs) specified during embryogenesis serve as progenitors to the adult germline stem cells. In Drosophila, the proper specification and formation of PGCs require both centrosomes and germ plasm, which contains the germline determinants. Centrosomes are microtubule (MT)-organizing centers that ensure the faithful segregation of germ plasm into PGCs. To date, mechanisms that modulate centrosome behavior to engineer PGC development have remained elusive. Only one germ plasm component, Germ cell-less (Gcl), is known to play a role in PGC formation. Here, we show that Gcl engineers PGC formation by regulating centrosome dynamics. Loss of gcl leads to aberrant centrosome separation and elaboration of the astral MT network, resulting in inefficient germ plasm segregation and aborted PGC cellularization. Importantly, compromising centrosome separation alone is sufficient to mimic the gcl loss-of-function phenotypes. We conclude Gcl functions as a key regulator of centrosome separation required for proper PGC development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.