Evidence map›Paper›PMID 28122228›Full record

ArticleCell reports2017

Temporally Distinct Six2-Positive Second Heart Field Progenitors Regulate Mammalian Heart Development and Disease.

Zhengfang Zhou, Jingying Wang, Chaoshe Guo, Weiting Chang, Jian Zhuang, Ping Zhu, Xue Li

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Article
  3. The molecular mechanisms of cardiac development and related diseases.Signal transduction and targeted therapy · 2024
    Review
  4. Cardiac Progenitor Cells of the First and Second Heart Fields.Advances in experimental medicine and biology · 2024
    Article
  5. Human Cardiac Development.Advances in experimental medicine and biology · 2024
    Article
  6. The second heart field: the first 20 years.Mammalian genome : official journal of the International Mammalian Genome Society · 2023
    Review
  7. Review
  8. Old Rivals in a New Track.Circulation research · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. The Skull's Girder: A Brief Review of the Cranial Base.Journal of developmental biology · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Zhengfang ZhouDepartments of Urology and Surgery, Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA; Department of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510100, China.
Jingying WangDepartments of Urology and Surgery, Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
Chaoshe GuoDepartments of Urology and Surgery, Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
Weiting ChangDivisions of Genetics and Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Jian ZhuangDepartment of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510100, China.
Ping ZhuDepartment of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510100, China. Electronic address: tanganqier@163.com.
Xue LiDepartments of Urology and Surgery, Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA. Electronic address: sean.li@childrens.harvard.edu.
Boston Children's Hospital · USBrigham and Women's Hospital · USGuangdong Academy of Medical Sciences · CNGuangdong General Hospital · CNHarvard University · US

Funding

The Six-Family Genes in Cardiovascular Development And DiseaseR01HL136921 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI LI, XUE SEAN · 2017 to 2020
$2.3M
Epithelial Signaling of Mammalian Facial TopologyR01DE019823 · NIDCR · BOSTON CHILDREN'S HOSPITAL · PI LI, XUE SEAN · 2009 to 2013
$2.1M
Functional characterizations of the Sdx1 domain during cloacal septationR01DK091645 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI LI, XUE SEAN · 2012 to 2012
$144k
NHLBI NIH HHS R01 HL136921NIDCR NIH HHS R01 DE019823NIDDK NIH HHS R01 DK091645
6 · The paper itself

Abstract

The embryonic process of forming a complex structure such as the heart remains poorly understood. Here, we show that Six2 marks a dynamic subset of second heart field progenitors. Six2-positive (Six2

Indexed as

AnimalsEchocardiographyEmbryo, MammalianHeartHeart DiseasesHeart VentriclesHedgehog ProteinsHomeodomain ProteinsIn Situ Hybridization, FluorescenceMiceMutagenesisMyocardiumRNA, MessengerSelective Estrogen Receptor ModulatorsSignal TransductionStem CellsHedgehog ProteinsHomeodomain ProteinsRNA, MessengerSelective Estrogen Receptor ModulatorsShh protein, mouseSix2 protein, mouseTamoxifenTranscription Factorscardiac neural crestcardiac outflow tractcommon arterial trunkdiphtheria toxin fragment ADTAhigh-resolution episcopic microscopyHREMintrapericardial arterial trunkpersistent truncus arteriosusprogenitorPTAsecond heart fieldShhSix1Six2tetralogy of FallotTOF

Identifiers

PMID28122228
PMCPMC7032615
OpenAlexW2580998780

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.