Evidence map›Paper›PMID 28122227›Full record

ArticleCell reports2017

Protection against High-Fat-Diet-Induced Obesity in MDM2

Shijie Liu, Tae-Hyung Kim, Derek A Franklin, Yanping Zhang

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Review
  3. NRH, a potent NADMetabolism: clinical and experimental · 2025
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  5. Molecular Variants inInternational journal of women's health · 2025
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  6. Article
  7. Article
  8. Article
  9. Article
  10. HepaticiScience · 2023
    Article
  11. Article
  12. Time-of-day defines NADNature communications · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Tubule-specific deletion ofMolecular therapy. Nucleic acids · 2021
    Article
  18. Article
  19. Article
  20. Chitosan from Crabs (Pathophysiology : the official journal of the International Society for Pathophysiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Shijie LiuDepartment of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7461, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7461, USA.
Tae-Hyung KimDepartment of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7461, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7461, USA.
Derek A FranklinDepartment of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7461, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7461, USA; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7461, USA.
Yanping ZhangDepartment of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7461, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7461, USA; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7461, USA; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical College, Xuzhou, Jiangsu 221002, China. Electronic address: ypzhang@med.unc.edu.
University of North Carolina at Chapel Hill · USXuzhou Medical College · CN

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SUSAN M. SMITH · 1999 to 2026
$31.6M
PREDOCTORAL TRAINING IN PHARMACOLOGICAL SCIST32GM007040 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NICHOLAS, ROBERT A · 1985 to 2019
$6.0M
Regulation of MDM2 by the ribosomal protein L11R01CA100302 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZHANG, YANPING · 2003 to 2013
$3.2M
The in vivo role of the Mdm2-MdmX interaction in p53 regulationR01CA167637 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZHANG, YANPING · 2012 to 2016
$1.5M
In vivo function of Mdm2 E3 ubiquitin ligaseR01CA127770 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZHANG, YANPING · 2008 to 2013
$1.5M
NCI NIH HHS P30 CA016086NCI NIH HHS R01 CA100302NCI NIH HHS R01 CA127770NCI NIH HHS R01 CA167637NIDDK NIH HHS P30 DK056350NIEHS NIH HHS P30 ES010126NIGMS NIH HHS T32 GM007040
6 · The paper itself

Abstract

The RPL11-MDM2 interaction constitutes a p53 signaling pathway activated by deregulated ribosomal biosynthesis in response to stress. Mice bearing an MDM2

Indexed as

Diet, High-FatAdipose TissueAnimalsCell DifferentiationCell LineEnergy MetabolismGene Expression RegulationGlucose Transporter Type 4LongevityMiceNADNicotinamide N-MethyltransferaseObesityPolymorphism, Single NucleotideProto-Oncogene Proteins c-mdm2Proto-Oncogene Proteins c-mycGlucose Transporter Type 4NADNicotinamide N-MethyltransferaseProto-Oncogene Proteins c-mdm2Proto-Oncogene Proteins c-mycRibosomal ProteinsSirtuin 1Tumor Suppressor Protein p53energy expenditurehigh-fat dietMDM2NAD(+)p53ribosomal protein

Identifiers

PMID28122227
PMCPMC5560502
OpenAlexW2581413639

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.