Evidence map›Paper›PMID 28122223›Full record

ArticleBiophysical journal2017

The Relaxation Properties of Myofibrils Are Compromised by Amino Acids that Stabilize α-Tropomyosin.

Beatrice Scellini, Nicoletta Piroddi, Alexander M Matyushenko, Dmitrii I Levitsky, Corrado Poggesi, Sherwin S Lehrer, Chiara Tesi

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Beatrice ScelliniDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Nicoletta PiroddiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Alexander M MatyushenkoA.N. Bach Institute of Biochemistry, Research Center of Biotechnology, Russian Academy of Sciences, Moscow, Russia.
Dmitrii I LevitskyA.N. Bach Institute of Biochemistry, Research Center of Biotechnology, Russian Academy of Sciences, Moscow, Russia.
Corrado PoggesiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Sherwin S LehrerDedham, Massachusetts.
Chiara TesiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy. Electronic address: chiara.tesi@unifi.it.
University of Florence · ITA N Bach Institute of Biochemistry · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the functional impact of α-tropomyosin (Tm) substituted with one (D137L) or two (D137L/G126R) stabilizing amino acid substitutions on the mechanical behavior of rabbit psoas skeletal myofibrils by replacing endogenous Tm and troponin (Tn) with recombinant Tm mutants and purified skeletal Tn. Force recordings from myofibrils (15°C) at saturating [Ca

Indexed as

Amino Acid SubstitutionMuscle RelaxationAnimalsCalciumHumansMyofibrilsProtein StabilityPsoas MusclesRabbitsSequence DeletionTropomyosinTroponin ICalciumTropomyosinTroponin I

Identifiers

PMID28122223
PMCPMC5266141
OpenAlexW2581317773

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.