ArticleBiophysical journal2017
Molecular-Scale Biophysical Modulation of an Endothelial Membrane by Oxidized Phospholipids.
Article in Biophysical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
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- Endothelial Stiffening Induced by CD36-Mediated Lipid Uptake Leads to Endothelial Barrier Disruption and Contributes to Atherosclerotic Lesions.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- The endothelial plasma membrane lipidome and its remodeling under hyperglycemia: an exploratory study.Frontiers in molecular biosciences · 2025Article
- PAFAH2 suppresses synchronized ferroptosis to ameliorate acute kidney injury.Nature chemical biology · 2024Article
- Liver X receptor agonist upregulates LPCAT3 in human aortic endothelial cells.Frontiers in physiology · 2024Article
- Effects of Nitro-Oxidative Stress on Biomolecules: Part 1-Non-Reactive Molecular Dynamics Simulations.Biomolecules · 2023Review
- OxPAPC stabilizes liquid-ordered domains in biomimetic membranes.Biophysical journal · 2023Article
- Activation of autophagy triggers mitochondrial loss and changes acetylation profile relevant for mechanotransduction in bladder cancer cells.Archives of toxicology · 2023Article
- Modelling Hyperglycaemia in an Epithelial Membrane Model: Biophysical Characterisation.Biomolecules · 2022Article
- Paradigms of endothelial stiffening in cardiovascular disease and vascular aging.Frontiers in physiology · 2022Review
- Going "Green" in the Prevention and Management of Atherothrombotic Diseases: The Role of Dietary Polyphenols.Journal of clinical medicine · 2021Review
- Simvastatin inhibits POVPC-mediated induction of endothelial-to-mesenchymal cell transition.Journal of lipid research · 2021Article
- Evaluating membrane structure by Laurdan imaging: Disruption of lipid packing by oxidized lipids.Current topics in membranes · 2021Review
- Selective LXR agonist DMHCA corrects retinal and bone marrow dysfunction in type 2 diabetes.JCI insight · 2020Article
- Lipid Organization in Mixed Lipid Membranes Driven by Intrinsic Curvature Difference.Biophysical journal · 2020Article
- LDL induces cholesterol loading and inhibits endothelial proliferation and angiogenesis in Matrigels: correlation with impaired angiogenesis during wound healing.American journal of physiology. Cell physiology · 2020Article
- Mechanisms of endothelial stiffening in dyslipidemia and aging: Oxidized lipids and shear stress.Current topics in membranes · 2020Review
- Article
- Functional impairment triggered by altertoxin II (ATXII) in intestinal cells in vitro: cross-talk between cytotoxicity and mechanotransduction.Archives of toxicology · 2018Article
- Membrane Stiffening in Osmotic Swelling: Analysis of Membrane Tension and Elastic Modulus.Current topics in membranes · 2018Article
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13 authors at 3 institutions in 1 country.
Funding
Abstract
The influence of two bioactive oxidized phospholipids on model bilayer properties, membrane packing, and endothelial cell biomechanics was investigated computationally and experimentally. The truncated tail phospholipids, 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC) and 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphocholine (PGPC), are two major oxidation products of the unsaturated phospholipid 1-palmitoyl-2-arachidonoyl-sn-glycero-phosphocholine. A combination of coarse-grained molecular dynamics simulations, Laurdan multiphoton imaging, and atomic force microscopy microindentation experiments was used to determine the impact of POVPC and PGPC on the structure of a multicomponent phospholipid bilayer and to assess the consequences of their incorporation on membrane packing and endothelial cell stiffness. Molecular simulations predicted differential bilayer perturbation effects of the two oxidized phospholipids based on the chemical identities of their truncated tails, including decreased bilayer packing, decreased bilayer bending modulus, and increased water penetration. Disruption of lipid order was consistent with Laurdan imaging results indicating that POVPC and PGPC decrease the lipid packing of both ordered and disordered membrane domains. Computational predictions of a larger membrane perturbation effect by PGPC correspond to greater stiffness of PGPC-treated endothelial cells observed by measuring cellular elastic moduli using atomic force microscopy. Our results suggest that disruptions in membrane structure by oxidized phospholipids play a role in the regulation of overall endothelial cell stiffness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.