ArticlePloS one2017
Intrinsic Functional Connectivity Alterations of the Primary Visual Cortex in Primary Angle-Closure Glaucoma Patients before and after Surgery: A Resting-State fMRI Study.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Neurophysiological Evidence of Visual Cortical Alterations in Mild Primary Glaucoma: A Resting-State EEG Microstate Study.Brain topography · 2026Article
- Neurophysiological Evidence of Visual Cortical Alterations in Mild Primary Glaucoma: A Resting-State EEG Microstate Study.Brain topography · 2026Article
- Characteristics of striatal changes in diabetic retinopathy and type 2 diabetes: a resting-state functional magnetic resonance imaging study.Frontiers in human neuroscience · 2026Article
- Resting-State fMRI Co-Activation Patterns Reveal Multiscale Brain Functional Alterations in Primary Angle-Closure Glaucoma: Transcriptomic, Cellular, Neurochemical, and Machine-Learning Signatures.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Hippocampal subregions functional connectivity alterations in primary angle-closure glaucoma patients with cognitive dysfunction: a resting-state fMRI study.BMC neurology · 2025Article
- Aberrant brain network connectivity related to cognitive and emotional regulation in women with abdominal obesity.Scientific reports · 2025Article
- Use of functional magnetic resonance imaging in the evaluation of neural plasticity in macular degeneration.Frontiers in neuroscience · 2025Review
- Specific static and dynamic functional network connectivity changes in thyroid-associated ophthalmopathy and it predictive values using machine learning.Frontiers in neuroscience · 2024Article
- Altered dynamic functional connectivity in the primary visual cortex in patients with primary angle-closure glaucoma.Frontiers in neuroscience · 2023Article
- Altered interhemispheric functional connectivity in patients with comitant exotropia before and after surgery: a resting-state fMRI study.Frontiers in human neuroscience · 2023Article
- Variant brain-derived neurotrophic factor val66met polymorphism engages memory-associated systems to augment olfaction.Scientific reports · 2022Article
- Altered functional connectivity of the thalamus in primary angle-closure glaucoma patients: A resting-state fMRI study.Frontiers in neurology · 2022Article
- Functional Connectivity Hypointensity of Middle Cingulate Gyrus and Thalamus in Age-Related Macular Degeneration Patients: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in aging neuroscience · 2022Article
- Relationships between cerebrovascular reactivity, visual-evoked functional activity, and resting-state functional connectivity in the visual cortex and basal forebrain in glaucoma.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2021Article
- Altered Functional Connectivity of the Primary Visual Cortex in Patients With Iridocyclitis and Assessment of Its Predictive Value Using Machine Learning.Frontiers in immunology · 2021Article
- Altered spontaneous neuronal activity and functional connectivity pattern in primary angle-closure glaucoma: a resting-state fMRI study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Altered intrinsic functional connectivity of the primary visual cortex in patients with retinal vein occlusion: a resting-state fMRI study.Quantitative imaging in medicine and surgery · 2020Article
- Altered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Corneal Ulcer: A Resting-State fMRI Study.Neuropsychiatric disease and treatment · 2020Article
- Altered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Neovascular Glaucoma: A Resting-State Functional Magnetic Resonance Imaging Study.Neuropsychiatric disease and treatment · 2020Article
- Intrinsic functional connectivity alterations of the primary visual cortex in patients with proliferative diabetic retinopathy: a seed-based resting-state fMRI study.Therapeutic advances in endocrinology and metabolism · 2020Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the altered intrinsic functional connectivity (iFC) of the primary visual cortex (V1) in primary angle-closure glaucoma (PACG) patients before and after surgery using resting-state functional MRI. MATERIALS AND
methodsTwenty-five preoperative PACG (pre-PACG) patients and 25 well-matched healthy controls (HCs) were included in this study, and 9 PACG patients were assessed again at least 3 months after treatment (post-PACG). We generated the iFC maps of the seed regions in the centers of the left and right V1 and conducted group comparisons. Then, the relationships between the altered iFC coefficients and clinical variables were investigated in the pre-PACG patients.
resultsCompared with the HCs, the pre-PACG patients showed decreased iFC between the left V1 and right V2 (covering the cuneus, calcarine and lingual gyrus) and increased iFC between the left V1 and left temporal-parietal region, left frontal opercula-insula-basal ganglia region, right insula-basal ganglia region, and right inferior parietal lobule (P < 0.01, corrected). Compared with the pre-PACG patients, the post-PACG patients showed increased iFC between the left V1 and bilateral V2, and between the left V1 and left or right postcentral gyrus; in addition, they showed decreased iFC between the left V1 and the dorsal-attention and frontoparietal-control networks. In the pre-PACG patients, visual activity (VA) was positively correlated with increased iFC between the left V1 and the left temporal-parietal region or the right inferior parietal lobule. Similar patterns of alterations were observed in the right V1-iFC in both the pre- and post-PACG patients.
conclusionsThe primary findings have demonstrated a gradual decrease in visual information integration in the left V1-V2 pathway and VA-related functional compensation in the pre-PACG patients, generating further evidence of functional restoration in post-PACG patients.
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