SynthesisPloS one2017
Reduced Ectopic Pregnancy Rate on Day 5 Embryo Transfer Compared with Day 3: A Meta-Analysis.
Synthesis in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Risk factors of ectopic pregnancy after in vitro fertilization-embryo transfer in Chinese population: A meta-analysis.PloS one · 2024Pooled it
- Should the flexibility enabled by performing a day-4 embryo transfer remain as a valid option in the IVF laboratory? A systematic review and network meta-analysis.Journal of assisted reproduction and genetics · 2019Pooled it
- A case series: thirty-three cases with heterotopic pregnancy after assisted reproductive technology.Frontiers in medicine · 2026Article
- The diagnosis and management of extrauterine and uterine ectopic pregnancy.Human reproduction update · 2026Review
- Association of endometrial preparation protocols and embryonic development stages with ectopic pregnancy in freeze-thaw cycles.Journal of assisted reproduction and genetics · 2025Article
- Impact of salpingectomy on the risk and characteristics of ectopic pregnancy after IVF/ICSI in patients with ectopic pregnancy history: A large retrospective cohort study.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Ectopic pregnancy.Nature reviews. Disease primers · 2024Review
- Determinants of Embryo Implantation: Roles of the Endometrium and Embryo in Implantation Success.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Top-quality embryo transfer is associated with lower odds of ectopic pregnancy.Acta obstetricia et gynecologica Scandinavica · 2022Article
- Intra-cavitary fluid resulted from caesarean section but not isthmocele compromised clinical pregnancy after IVF/ICSI treatment.Archives of gynecology and obstetrics · 2022Article
- Tubal factor, cleavage stage and more than one embryo transferred were risk factors associated with ectopic pregnancy after assisted reproductive treatment.JBRA assisted reproduction · 2022Article
- An Endometrial Thickness < 8 mm Was Associated With a Significantly Increased Risk of EP After Freeze-Thaw Transfer: An Analysis of 5,960 Pregnancy Cycles.Frontiers in endocrinology · 2022Article
- Article
- Effect of endometrial preparation protocols on the risk of ectopic pregnancy for frozen embryo transfer.Scientific reports · 2021Article
- Article
- Concordance between systematic reviews of randomized controlled trials in assisted reproduction: an overview.Human reproduction open · 2020Review
- Correlation between Ovarian Reserve and Incidence of Ectopic Pregnancy afterYonsei medical journal · 2019Observational
- Heterotopic Quadruplet Pregnancy After ICSI Conception.Journal of obstetrics and gynaecology of India · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare the risk of ectopic pregnancy (EP) after embryo transfer on day 3(D3-ET) and day 5(D5-ET).
designMeta-analysis. PATIENTS: Women with pregnancy resulting from in vitro undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). RESULT(S): Twenty-two studies were identified through research conducted using the PubMed, Embase, and Cochrane databases and ClinicalTrials.gov. All studies were conducted prior to October 2016. Adding the reproductive data from our center, a total of 143 643 pregnancies were reviewed(D3-ET: n = 62027,D5-ET:n = 81616). A lower EP rate was found in women undergoing D5-ET than in those undergoing D3-ET [relative risk (RR), 0.67;95% confidence interval (CI), 0.54-0.85;143643 pregnancies in 23 studies; I2 = 67%]. These results were validated in subgroups of fresh embryo-transfer (Fre-ET) cycles [RR, 0.78; 95%CI, 0.69-0.88; 91 871 pregnancies in 21 studies; I2 = 29%] and frozen-thawed embryo-transfer (Fro-ET) cycles [RR, 0.43; 95%CI, 0.36-0.51; 51 772 pregnancies in 10 studies; I2 = 33%]. After separating out the randomized controlled trials (RCTs), a significant difference was found in the retrospective studies in both subgroups [both Fre-ET (RR,0.78;95% CI 0.69-0.88);91182 pregnancies in 14 studies; I2 = 45%] and Fro-ET(RR,0.43;95% CI 0.36-0.51; 51751pregnancies in 9 studies;I2 = 33%)], while the RCTs showed no statistical significance for Fre-ET cycles[RR,0.86;95% CI 0.32-2.26); 689 pregnancies in 7 studies; I2 = 0%]. CONCLUSION(S): The present study indicates that D5-ET reduces the risk for EP in cycles that use IVF or ICSI, compared with D3-ET. It suggests that D5-ET may be a better choice for decreasing the EP rate in assisted reproductive technology. Further high-quality randomized controlled trials are anticipated.
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