ArticlePLoS genetics2017
Genetic Variation in the Social Environment Contributes to Health and Disease.
Article in PLoS genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed.
- Article
- Discovery and characterization of gene-by-environment and epistatic genetic effects in a vertebrate model.Cell genomics · 2026Article
- Genetic architecture and mechanisms of host-microbiome interactions from a multi-cohort analysis of outbred laboratory rats.Nature communications · 2025Article
- Novel insights into the genetic architecture and mechanisms of host/microbiome interactions from a multi-cohort analysis of outbred laboratory rats.bioRxiv : the preprint server for biology · 2025Article
- Towards assessing indirect genetic effects in dairy cattle.Genetics, selection, evolution : GSE · 2025Article
- Measurement and classification of bold-shy behaviours in medaka fish.Bioinformatics (Oxford, England) · 2025Article
- Transcriptomic and Proteomic Analyses of the Liver and Ileum Identify Key Genes and Pathways Associated with Low and High Groups of Social Genetic Effect of Residual Feed Intake.Animals : an open access journal from MDPI · 2025Article
- Validation studies and multiomics analysis of Zhx2 as a candidate quantitative trait gene underlying brain oxycodone metabolite (oxymorphone) levels and behavior.The Journal of pharmacology and experimental therapeutics · 2025Article
- Indirect genetic effects increase the heritable variation available to selection and are largest for behaviors: a meta-analysis.Evolution letters · 2025Article
- Peer Social Genetic Effects and the Etiology of Substance Use Disorders, Major Depression, and Anxiety Disorder in a Swedish National Sample.The American journal of psychiatry · 2024Article
- Accelerated hermaphrodite maturation on male pheromones suggests a general principle of coordination between larval behavior and development.Development (Cambridge, England) · 2024Article
- Genetic correlations of direct and indirect genetic components of social dominance with fitness and morphology traits in cattle.Genetics, selection, evolution : GSE · 2023Article
- Correlations in sleeping patterns and circadian preference between spouses.Communications biology · 2023Article
- Partners in Health: Investigating Social Genetic Effects Among Married and Cohabiting Couples.Behavior genetics · 2023Article
- A complete absence of indirect genetic effects on brain gene expression in a highly social context.Molecular ecology · 2022Article
- Article
- Cascading indirect genetic effects in a clonal vertebrate.Proceedings. Biological sciences · 2022Article
- The Indirect Genetic Effect Interaction Coefficient ψ: Theoretically Essential and Empirically Neglected.The Journal of heredity · 2022Article
- Indirect Genetic Effects: A Cross-disciplinary Perspective on Empirical Studies.The Journal of heredity · 2022Article
- Article
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11 authors.
Funding
Abstract
Assessing the impact of the social environment on health and disease is challenging. As social effects are in part determined by the genetic makeup of social partners, they can be studied from associations between genotypes of one individual and phenotype of another (social genetic effects, SGE, also called indirect genetic effects). For the first time we quantified the contribution of SGE to more than 100 organismal phenotypes and genome-wide gene expression measured in laboratory mice. We find that genetic variation in cage mates (i.e. SGE) contributes to variation in organismal and molecular measures related to anxiety, wound healing, immune function, and body weight. Social genetic effects explained up to 29% of phenotypic variance, and for several traits their contribution exceeded that of direct genetic effects (effects of an individual's genotypes on its own phenotype). Importantly, we show that ignoring SGE can severely bias estimates of direct genetic effects (heritability). Thus SGE may be an important source of "missing heritability" in studies of complex traits in human populations. In summary, our study uncovers an important contribution of the social environment to phenotypic variation, sets the basis for using SGE to dissect social effects, and identifies an opportunity to improve studies of direct genetic effects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.