Evidence map›Paper›PMID 28121926›Full record

ArticleMedicine2017

Inflammation as a contributing factor among postmenopausal Saudi women with osteoporosis.

Nasser M Al-Daghri, Ibrahim Aziz, Sobhy Yakout, Naji J Aljohani, Yousef Al-Saleh, Osama E Amer, Eman Sheshah, Ghaida Zakaria Younis, Fahad Badr M Al-Badr

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In one paragraph

Article in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Nasser M Al-DaghriPrince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University Obesity, Endocrine and Metabolism Center, King Fahad Medical City, Faculty of Medicine College of Medicine, King Saud bin Abdulaziz University for Health Sciences Diabetes Care Center, King Salman Bin Abdulaziz Hospital Department of Radiology and Medical Imaging, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
Ibrahim Aziz
Sobhy Yakout
Naji J Aljohani
Yousef Al-Saleh
Osama E Amer
Eman Sheshah
Ghaida Zakaria Younis
Fahad Badr M Al-Badr
King Saud bin Abdulaziz University for Health Sciences · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postmenopausal osteoporosis is an important metabolic bone disease characterized by rapid bone loss occurring in the postmenopausal period. Recently, the most prevalent form of clinically significant osteopenia and osteoporosis involves various inflammatory conditions. The aim of the study is to evaluate the association between proinflammatory markers (interleukin [IL]-1β, IL-6, TNF-α) with bone turnover markers (BTMs) in postmenopausal Saudi women with and without osteoporosis. A total of 200 postmenopausal Saudi women ≥50 years old, 100 with osteoporosis and 100 without osteoporosis (control) were recruited under the supervision of qualified physicians in King Salman Hospital and King Fahd Medical City, Riyadh, Saudi Arabia. Serum tumor necrosis factor alpha (TNF-α), IL-1, IL-4, IL-6, and parathyroid hormone (PTH) were determined using Luminex xMAP technology. N-telopeptides of collagen type I (NTx) was assessed using ELISA, 25(OH) vitamin D and osteocalcin were determined using electrochemiluminescence, serum calcium and inorganic phosphate (Pi) were measured by a chemical analyzer. Serum IL-1β, IL-6, NTx, and PTH levels in women with osteoporosis were significantly higher than controls. Although IL-4 and osteocalcin were significantly lower than controls. IL-1β and TNF-α were positively associated with NTx in osteoporosis women. TNF-α, IL-6, and TNF-α were positively correlated with IL-lβ in both groups. A significant negative correlation between osteocalcin and IL-1β in healthy women and women with osteoporosis were observed. Findings of the present study implicate a role for cytokine pattern-mediated inflammation in patients with osteoporosis.

Indexed as

BiomarkersBone RemodelingCalciumCase-Control StudiesCollagen Type IFemaleHumansInflammationInterleukin-1betaInterleukin-4Interleukin-6Middle AgedOsteocalcinOsteoporosis, PostmenopausalParathyroid HormonePeptides25-hydroxyvitamin DBiomarkersCalciumCollagen Type Icollagen type I trimeric cross-linked peptideIL1B protein, humanIL4 protein, humanIL6 protein, humanInterleukin-1betaInterleukin-4Interleukin-6OsteocalcinParathyroid HormonePeptidesPhosphatesTumor Necrosis Factor-alphaVitamin D

Identifiers

PMID28121926
PMCPMC5287950
OpenAlexW2579950070

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.