ArticleJournal of the American Chemical Society2017
Polymer Structure and Conformation Alter the Antigenicity of Virus-like Particle-Polymer Conjugates.
Article in Journal of the American Chemical Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Combinatorial Synthesis of Protein-Polymer Conjugates by Postpolymerization Modification of Poly(pentafluorophenyl acrylate)s.ACS omega · 2026Article
- Immunogenicity Management Strategies for PEGylated Drug Delivery Systems.International journal of nanomedicine · 2026Review
- Polymeric Nanoparticles for Drug Delivery.Chemical reviews · 2024Review
- Surface Cross-Linking by Macromolecular Tethers Enhances Virus-like Particles' Resilience to Mucosal Stress Factors.ACS nano · 2024Article
- Water-soluble polyphosphonate-based bottlebrush copolymersChemical science · 2023Article
- Preparation and Biological Properties of Oligonucleotide-Functionalized Virus-like Particles.Biomacromolecules · 2023Article
- Recent development and application of membrane chromatography.Analytical and bioanalytical chemistry · 2023Review
- Polynorbornene-based bioconjugates by aqueous grafting-from ring-opening metathesis polymerization reduce protein immunogenicity.Cell reports. Physical science · 2022Article
- Simulation of the Coronal Dynamics of Polymer-Grafted Nanoparticles.ACS polymers Au · 2022Article
- Polymer Chemistry for Haptics, Soft Robotics, and Human-Machine Interfaces.Advanced functional materials · 2021Article
- Single-Point Mutations in Qβ Virus-like Particles Change Binding to Cells.Biomacromolecules · 2021Article
- Improvement of RG1-VLP vaccine performance in BALB/c mice by substitution of alhydrogel with the next generation polyphosphazene adjuvant PCEP.Human vaccines & immunotherapeutics · 2021Article
- Next generation polyphosphazene immunoadjuvant: Synthesis, self-assembly and in vivo potency with human papillomavirus VLPs-based vaccine.Nanomedicine : nanotechnology, biology, and medicine · 2021Article
- Degradable Polyphosphoramidate via Ring-Opening Metathesis Polymerization.ACS macro letters · 2020Article
- It is Better with Salt: Aqueous Ring-Opening Metathesis Polymerization at Neutral pH.Journal of the American Chemical Society · 2020Article
- Mapping protein-polymer conformations in bioconjugates with atomic precision.Chemical science · 2020Article
- In Pursuit of Zero 2.0: Recent Developments in Nonfouling Polymer Brushes for Immunoassays.Advanced materials (Deerfield Beach, Fla.) · 2020Review
- Architectural Modification of Conformal PEG-Bottlebrush Coatings Minimizes Anti-PEG Antigenicity While Preserving Stealth Properties.Advanced healthcare materials · 2019Article
- Polymer conjugation of proteins as a synthetic post-translational modification to impact their stability and activity.Polymer chemistry · 2019Article
- A guide to maximizing the therapeutic potential of protein-polymer conjugates by rational design.Chemical Society reviews · 2018Review
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Covalent conjugation of water-soluble polymers to proteins is critical for evading immune surveillance in the field of biopharmaceuticals. The most common and long-standing polymer modification is the attachment of methoxypoly(ethylene glycol) (mPEG), termed PEGylation, which has led to several clinically approved pharmaceuticals. Recent data indicate that brush-type polymers significantly enhance in vitro and in vivo properties. Herein, the polymer conformation of poly(ethylene glycol) is detailed and compared with those of water-soluble polyacrylate and polynorbornene (PNB) when attached to icosahedral virus-like particles. Small-angle neutron scattering reveals vastly different polymer conformations of the multivalent conjugates. Immune recognition of conjugated particles was evaluated versus PEGylated particles, and PNB conjugation demonstrated the most effective shielding from antibody recognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.