Evidence map›Paper›PMID 28121262›Full record

ArticleCancer biology & therapy2017

Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer.

Sujuan Yang, Sara P Y Che, Paul Kurywchak, Jena L Tavormina, Liv B Gansmo, Pedro Correa de Sampaio, Michael Tachezy, Maximilian Bockhorn, Florian Gebauer, Amanda R Haltom and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer biology & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

142 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Strategy for early diagnosis of pancreatic cancer.Frontiers in gastroenterology (Lausanne, Switzerland) · 2026
    Review
  11. Frontiers in cellular neuroscience · 2026
    Review
  12. Review
  13. Engineered exosomes with KrasNature communications · 2025
    Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Small extracellular vesicles (sEVs) in pancreatic cancer progression and diagnosis.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Review
  19. Review
  20. Article

82 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sujuan Yanga Department of Cancer Biology , Metastasis Research Center, University of Texas MD Anderson Cancer Center , Houston , TX , USA.
Sara P Y Chea Department of Cancer Biology , Metastasis Research Center, University of Texas MD Anderson Cancer Center , Houston , TX , USA.
Paul Kurywchaka Department of Cancer Biology , Metastasis Research Center, University of Texas MD Anderson Cancer Center , Houston , TX , USA.
Jena L Tavorminaa Department of Cancer Biology , Metastasis Research Center, University of Texas MD Anderson Cancer Center , Houston , TX , USA.
Liv B Gansmoa Department of Cancer Biology , Metastasis Research Center, University of Texas MD Anderson Cancer Center , Houston , TX , USA.
Pedro Correa de Sampaioa Department of Cancer Biology , Metastasis Research Center, University of Texas MD Anderson Cancer Center , Houston , TX , USA.
Michael Tachezyb Department of General , Visceral and Thoracic Surgery, University Medical Center of Hamburg-Eppendorf , Hamburg , Germany.
Maximilian Bockhornb Department of General , Visceral and Thoracic Surgery, University Medical Center of Hamburg-Eppendorf , Hamburg , Germany.
Florian Gebauerb Department of General , Visceral and Thoracic Surgery, University Medical Center of Hamburg-Eppendorf , Hamburg , Germany.
Amanda R Haltoma Department of Cancer Biology , Metastasis Research Center, University of Texas MD Anderson Cancer Center , Houston , TX , USA.
Sonia A Meloc Instituto de Investigação e Inovação em Saúde, Universidade do Porto , Porto , Portugal (I3S).
Valerie S LeBleua Department of Cancer Biology , Metastasis Research Center, University of Texas MD Anderson Cancer Center , Houston , TX , USA.
Raghu Kalluria Department of Cancer Biology , Metastasis Research Center, University of Texas MD Anderson Cancer Center , Houston , TX , USA.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Kathrin Milbury · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

Pancreatic cancer presents with a dismal mortality rate and is in urgent need of methods for early detection with potential for timely intervention. All living cells, including cancer cells, generate exosomes. We previously discovered double stranded genomic DNA in exosomes derived from the circulation of pancreatic cancer patients, which enabled the detection of prevalent mutations associated with the disease. Here, we report a proof-of-concept study that demonstrates the potential clinical utility of circulating exosomal DNA for identification of KRAS

Indexed as

Case-Control StudiesCell Line, TumorDNADNA, NeoplasmExosomesHumansMutationPancreatic NeoplasmsPolymerase Chain ReactionProto-Oncogene Proteins p21(ras)Tumor Suppressor Protein p53DNADNA, NeoplasmKRAS protein, humanProto-Oncogene Proteins p21(ras)TP53 protein, humanTumor Suppressor Protein p53Circulating exosomal DNAdigital PCRexosomeKRASliquid biopsypancreatic cancerTP53

Identifiers

PMID28121262
PMCPMC5389423

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.