ReviewThe Journal of neuropsychiatry and clinical neurosciences2017
Neurobiology of the Premonitory Urge in Tourette's Syndrome: Pathophysiology and Treatment Implications.
Review in The Journal of neuropsychiatry and clinical neurosciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05269953 (A Randomised, Double-blind, Placebo-controlled, Trial of Rhythmic 10Hz Median Nerve Stimulation for the Suppression of the Urge-to-tic and Reduction of Tics in Individuals With Tourette Syndrome and Chronic Tic Disorder), which is not on this map. Cited by 58 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomised, Double-blind, Placebo-controlled, Trial of Rhythmic 10Hz Median Nerve Stimulation for the Suppression of the Urge-to-tic and Reduction of Tics in Individuals With Tourette Syndrome and Chronic Tic Disorder
Who cites it
58 citing papers in PubMed, 4 syntheses or guidelines pooled it, 196 citations in OpenAlex.
- Premonitory urge in tic disorders - a scoping review.Frontiers in psychiatry · 2025Pooled it
- Non-invasive brain stimulation as therapy: systematic review and recommendations with a focus on the treatment of Tourette syndrome.Experimental brain research · 2022Pooled it
- Tourette syndrome research highlights from 2017.F1000Research · 2018Pooled it
- Centrality of prefrontal and motor preparation cortices to Tourette Syndrome revealed by meta-analysis of task-based neuroimaging studies.NeuroImage. Clinical · 2017Pooled it
- Endocannabinoid Modulation Using Monoacylglycerol Lipase Inhibition in Tourette Syndrome: A Phase 1 Randomized, Placebo-Controlled Study.Pharmacopsychiatry · 2022Trial
- Aberrant brain functional connectivity is associated with clinical symptoms in tourette syndrome: a triple network model perspective.European child & adolescent psychiatry · 2026Article
- What can clinical disorders involving the basal ganglia tell us about the pathophysiology of obsessive and compulsive symptoms?Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Contemporary Perspectives on Neurobiology and Treatment of Tic Disorders: A Narrative Review.Journal of the Korean Academy of Child and Adolescent Psychiatry · 2026Article
- Beyond the Homunculus-SCAN-AMN as a Shared Action-Oriented Neural Substrate across Movement Disorders.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- The Role of Digital Tools in Meeting the Needs of Adults With Tourette Syndrome: A Human-Centered Design Approach.JMIR formative research · 2026Article
- Thalamo-frontal functional connectivity patterns in Tourette Syndrome: Insights from combined intracranial DBS and EEG recordings.Molecular psychiatry · 2026Article
- Functional connectivity of the precuneus and posterior cingulate cortex moderates the relationship between tic symptoms and premonitory urge in tourette syndrome.European child & adolescent psychiatry · 2025Article
- Action-mode subnetworks for decision-making, action control, and feedback.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Simple and Complex Phonic Tics in Tourette Syndrome.Brain sciences · 2025Article
- Alterations of sensorimotor predictive processes and their electrophysiological signatures in Tourette syndrome.Brain communications · 2025Article
- Transcranial magnetic stimulation to probe the role of the supplementary motor area in tics.Frontiers in human neuroscience · 2025Article
- A critical role of action-related functional networks in Gilles de la Tourette syndrome.Nature communications · 2024Article
- Identifying subgroups of urge suppression in Obsessive-Compulsive Disorder using machine learning.Journal of psychiatric research · 2024Article
- When the interoceptive and conceptual clash: The case of oppositional phenomenal self-modelling in Tourette syndrome.Cognitive, affective & behavioral neuroscience · 2024Review
- Exploring the psychometric properties of the premonitory urge for tics scale (PUTS) and its association with psychiatric symptoms in Chinese children with tic disorders.BMC pediatrics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Motor and vocal tics are relatively common motor manifestations identified as the core features of Tourette's syndrome (TS). Although traditional descriptions have focused on objective phenomenological observations, such as anatomical location, number and frequency of tics, patients' first-person accounts have consistently reported characteristic subjective correlates. These sensory phenomena are often described as a feeling of mounting inner tension or urge to move ("premonitory urge"), which is transiently relieved by tic expression. This article reviews the existing literature on the clinical and neurobiological aspects of the premonitory urge in patients with TS, with focus on its pathophysiology and possible treatment implications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.