ArticleJournal of cellular and molecular medicine2017
A functional variant in ST2 gene is associated with risk of hypertension via interfering MiR-202-3p.
Article in Journal of cellular and molecular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Association of IL-1RAcP rs16865597 gene polymorphism with susceptibility to essential hypertension: a case-control study in the Chinese Han population.BMC cardiovascular disorders · 2025Article
- The Influence of Genetic Polymorphisms ofInternational journal of dentistry · 2025Article
- Soluble ST2: A Novel Biomarker for Diagnosis and Prognosis of Cardiovascular Disease.Current medical science · 2024Review
- Review
- Expression of soluble ST2 in patients with essential hypertension and its relationship with left ventricular hypertrophy.ESC heart failure · 2023Article
- Association ofFrontiers in cardiovascular medicine · 2021Article
- Genetic Association of Interleukin 33/ST2 Polymorphisms With Behcet's Uveitis.Frontiers in immunology · 2021Article
- Blood microRNA 202-3p associates with the risk of essential hypertension by targeting soluble ST2.Bioscience reports · 2020Article
- Article
- MicroRNA-202-3p Targets Brain-Derived Neurotrophic Factor and Is Involved in Depression-Like Behaviors.Neuropsychiatric disease and treatment · 2020Article
- Overexpression of microRNA-202-3p protects against myocardial ischemia-reperfusion injury through activation of TGF-β1/Smads signaling pathway by targeting TRPM6.Cell cycle (Georgetown, Tex.) · 2019Article
- Association between functional polymorphisms in IL-33/ST2 pathway and risk of osteosarcoma.Journal of cellular and molecular medicine · 2018Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have suggested that interleukin 1 receptor-like 1 (ST2) plays a critical role in pathogenesis of several cardiovascular disease conditions. In this study, we examined association of 13 single nucleotide polymorphisms (SNPs) of ST2 gene with essential hypertension (EH) risk in 1151 patients with EH and 1135 controls. Our study showed that variants rs11685424, rs12999364 and rs3821204 are highly associated with an increase in risk of EH, while rs6543116 is associated with a decrease risk of EH. Notably, in silico analyses suggested the G>C change of rs3821204, which located within the 3'UTR of soluble ST2 mRNA, disrupted a putative binding site for miR202-3p. Functional analyses suggested that miR-202-3p significantly decreased soluble ST2-G mRNA stability and inhibited its endogenous expression. Furthermore, we found increased plasma-soluble ST2 (sST2) level was highly associated with CC genotype of rs3821204 in vivo. Taken together, our findings provide the first evidence that genetic variants in ST2 gene are associated with EH risk and variant rs3821204 may influence the development of EH by controlling sST2 expression.
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