ReviewThe British journal of surgery2017
The gut microbiome and the mechanism of surgical infection.
Review in The British journal of surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 3 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- A meta-analysis of the effects of preoperative mechanical intestinal preparation and oral antibiotics on surgical site infection after rectal tumor resection.Updates in surgery · 2026Pooled it
- Pooled it
- Naturopathic Treatment and Complementary Medicine in Surgical Practice.Deutsches Arzteblatt international · 2018Pooled it
- The unrestricted global effort to complete the COOL trial.World journal of emergency surgery : WJES · 2023Trial
- Oral neomycin and bacitracin are effective in preventing surgical site infections in elective colorectal surgery: a multicentre, randomized, parallel, single-blinded trial (COLORAL-1).Updates in surgery · 2021Trial
- Prevention of anastomotic leak in rectal cancer surgery with local antibiotic decontamination: a prospective, randomized, double-blind, placebo-controlled single center trial.International journal of colorectal disease · 2020Trial
- Article
- Modulation of the gut microbiota as a novel strategy to prevent anastomotic leak after colorectal surgery: Systematic scoping review.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026Article
- Perioperative selective decontamination of the digestive tract does not improve postoperative infectious complications after gastrectomy: a propensity score-matched analysis.Langenbeck's archives of surgery · 2026Article
- Post-Surgical Gut Microbiota Alterations in Pediatric Patients with Intestinal Disorders.Journal of clinical medicine · 2026Review
- Multimodal biomarker panel for early prediction of anastomotic leak after colorectal surgery: from inflammation to ischemia.Frontiers in surgery · 2026Review
- Perioperative gut microbiota homeostasis and its interactions with anesthetic agents: recent advances.American journal of translational research · 2026Review
- Bowel-Related Symptoms and Dietary Fiber Intake in Colorectal Cancer Survivors.JAMA network open · 2025Observational
- Perioperative changes in the microbiome during rectal cancer surgery: exploratory analysis of the National Institute for Health and Care Research (NIHR) IntAct trial.The British journal of surgery · 2025Article
- Pilot Study: Investigating the Local Breast Microbiome in Implant-based Breast Reconstruction Using 16S rRNA Sequencing.Plastic and reconstructive surgery. Global open · 2025Article
- Efficacy of a Shortened Oral Antibiotic Bowel Decontamination in Minimally Invasive Surgery for Diverticular Disease.Visceral medicine · 2025Article
- Aging-induced Alternation in the Gut Microbiota Impairs Host Antibacterial Defense.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A Smart Semi-Implantable Device Integrating Microchannel-Enhanced Sampling and Multiplex Biochemical Testing for Deep Wound Monitoring and Pathogen Identification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Advancements in postoperative pancreatic fistula: a comprehensive review of predictive factors, therapies, scoring systems and ongoing trials.eGastroenterology · 2025Review
- Multi-omics perspective: mechanisms of gastrointestinal injury repair.Burns & trauma · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundSince the very early days of surgical practice, surgeons have recognized the importance of considering that intestinal microbes might have a profound influence on recovery from surgical diseases such as appendicitis and peritonitis. Although the pathogenesis of surgical diseases such as cholelithiasis, diverticulosis, peptic ulcer disease and cancer have been viewed as disorders of host biology, they are emerging as diseases highly influenced by their surrounding microbiota.
methodsThis is a review of evolving concepts in microbiome sciences across a variety of surgical diseases and disorders, with a focus on disease aetiology and treatment options.
resultsThe discovery that peptic ulcer disease and, in some instances, gastric cancer can now be considered as infectious diseases means that to advance surgical practice humans need to be viewed as superorganisms, consisting of both host and microbial genes. Applying this line of reasoning to the ever-ageing population of patients demands a more complete understanding of the effects of modern-day stressors on both the host metabolome and microbiome.
conclusionDespite major advances in perioperative care, surgeons today are witnessing rising infection-related complications following elective surgery. Many of these infections are caused by resistant and virulent micro-organisms that have emerged as a result of human progress, including global travel, antibiotic exposure, crowded urban conditions, and the application of invasive and prolonged medical and surgical treatment. A more complete understanding of the role of the microbiome in surgical disease is warranted to inform the path forward for prevention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.