ArticleEvolution; international journal of organic evolution2017
Dynamics of molecular evolution in RNA virus populations depend on sudden versus gradual environmental change.
Article in Evolution; international journal of organic evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Taylor's Power Law rules the dynamics of allele frequencies during viral evolution in response to host changes.Journal of the Royal Society, Interface · 2025Article
- Fluctuating selection facilitates the discovery of broadly effective but difficult to reach adaptive outcomes in yeast.Evolution letters · 2024Article
- Innovation in viruses: fitness valley crossing, neutral landscapes, or just duplications?Virus evolution · 2024Article
- Mechanisms for the circulation of influenza A(H3N2) in China: A spatiotemporal modelling study.PLoS pathogens · 2022Article
- Article
- Fluctuating Environments Maintain Genetic Diversity through Neutral Fitness Effects and Balancing Selection.Molecular biology and evolution · 2021Article
- Intra-Population Competition during Adaptation to Increased Temperature in an RNA Bacteriophage.International journal of molecular sciences · 2021Article
- A network-based approach to deciphering a dynamic microbiome's response to a subtle perturbation.Scientific reports · 2020Article
- Article
- Profile of Paul E. Turner.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Broad and Dynamic Diversification of Infectious Hepatitis C Virus in a Cell Culture Environment.Journal of virology · 2020Article
- Article
- Article
- Evolutionary Dynamics in the RNA Bacteriophage Qβ Depends on the Pattern of Change in Selective Pressures.Pathogens (Basel, Switzerland) · 2019Article
- Existing Host Range Mutations Constrain Further Emergence of RNA Viruses.Journal of virology · 2019Article
- Recombination drives the evolution of mutational robustness.Current opinion in systems biology · 2019Article
- The phylogenomics of evolving virus virulence.Nature reviews. Genetics · 2018Review
- Evolutionary adaptation of an RNA bacteriophage to the simultaneous increase in the within-host and extracellular temperatures.Scientific reports · 2018Article
- Mapping the Evolutionary Potential of RNA Viruses.Cell host & microbe · 2018Review
- Adaptations of an RNA virus to increasing thermal stress.PloS one · 2017Article
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2 authors.
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Abstract
Understanding the dynamics of molecular adaptation is a fundamental goal of evolutionary biology. While adaptation to constant environments has been well characterized, the effects of environmental complexity remain seldom studied. One simple but understudied factor is the rate of environmental change. Here we used experimental evolution with RNA viruses to investigate whether evolutionary dynamics varied based on the rate of environmental turnover. We used whole-genome next-generation sequencing to characterize evolutionary dynamics in virus populations adapting to a sudden versus gradual shift onto a novel host cell type. In support of theoretical models, we found that when populations evolved in response to a sudden environmental change, mutations of large beneficial effect tended to fix early, followed by mutations of smaller beneficial effect; as predicted, this pattern broke down in response to a gradual environmental change. Early mutational steps were highly parallel across replicate populations in both treatments. The fixation of single mutations was less common than sweeps of associated "cohorts" of mutations, and this pattern intensified when the environment changed gradually. Additionally, clonal interference appeared stronger in response to a gradual change. Our results suggest that the rate of environmental change is an important determinant of evolutionary dynamics in asexual populations.
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