Evidence map›Paper›PMID 28120945›Full record

ArticleScientific reports2017

Imorin: a sexual attractiveness pheromone in female red-bellied newts (Cynops pyrrhogaster).

Tomoaki Nakada, Fumiyo Toyoda, Kouhei Matsuda, Takashi Nakakura, Itaru Hasunuma, Kazutoshi Yamamoto, Satomi Onoue, Makoto Yokosuka, Sakae Kikuyama

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Pheromone Response and Mating Behavior in Fission Yeast.Microbiology and molecular biology reviews : MMBR · 2022
    Review
  6. Dermocystid infection in Japanese fire-bellied newt, Cynops pyrrhogaster.The Journal of veterinary medical science · 2022
    Article
  7. Pheromonal communication in urodelan amphibians.Cell and tissue research · 2021
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Tomoaki NakadaDepartment of Veterinary Medicine, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo 180-8602, Japan.
Fumiyo ToyodaDepartment of Physiology, Nara Medical University, Nara 634-8521, Japan.
Kouhei MatsudaLaboratory of Regulatory Biology, Graduate School of Science and Engineering, University of Toyama, Toyama 930-8555, Japan.
Takashi NakakuraDepartment of Anatomy and Cell Biology, Teikyo University School of Medicine, Tokyo 173-8605, Japan.
Itaru HasunumaDepartment of Biology, Faculty of Science, Toho University, Chiba 274-8510, Japan.
Kazutoshi YamamotoDepartment of Biology, Faculty of Education and Integrated Sciences, Waseda University, Tokyo 169-8050, Japan.
Satomi OnoueDepartment of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan.
Makoto YokosukaDepartment of Veterinary Medicine, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo 180-8602, Japan.
Sakae KikuyamaDepartment of Biology, Faculty of Education and Integrated Sciences, Waseda University, Tokyo 169-8050, Japan.
Nippon Veterinary and Life Science University · JPWaseda University · JPNara Medical University · JPTeikyo University · JPToho University · JPUniversity of Shizuoka · JPUniversity of Toyama · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The male red-bellied newt (Cynops pyrrhogaster) approaches the female's cloaca prior to performing any courtship behaviour, as if he is using some released substance to gauge whether she is sexually receptive. Therefore, we investigated whether such a female sexual attractiveness pheromone exists. We found that a tripeptide with amino acid sequence Ala-Glu-Phe is secreted by the ciliary cells in the epithelium of the proximal portion of the oviduct of sexually developed newts and confirmed that this is the major active substance in water in which sexually developed female newts have been kept. This substance only attracted sexually developed male newts and acted by stimulating the vomeronasal epithelial cells. This is the first female sexual attractiveness peptide pheromone to be identified in a vertebrate.

Indexed as

AnimalsDipeptidesFemaleMaleOviductsSalamandridaeSex AttractantsVomeronasal OrganDipeptidesphenylalanylglutamateSex Attractants

Identifiers

PMID28120945
PMCPMC5264602
OpenAlexW2581536180

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.