ArticleScientific reports2017
Evidence for positive selection and recombination hotspots in Deformed wing virus (DWV).
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
- Co-inoculation with deformed wing virus and sacbrood virus affects viral and immune dynamics and synergistically increases honey bee mortality.PLoS pathogens · 2026Article
- Opposite seasonal and spatial dynamics of DWV-A and DWV-B suggest distinct transmission pathways in managed honey bees (Apis mellifera L.) colonies.Scientific reports · 2026Article
- Bumble Bees and Honey Bees on Islands Harbour Reduced Viral Species Richness, Yet Honey Bee Populations Are Dominated by a Deformed Wing Virus Recombinant.Molecular ecology · 2025Article
- Parasitic Mites of Honey Bees (Apis Spp.): A Detailed Review of Varroa destructor in Parasitism, Pathogen Transmission and its Management.Acta parasitologica · 2025Review
- Superinfection Exclusion in Neotropical Honey Bees May Block DWV-B, an Emerging Infectious Disease Variant of Deformed Wing Virus.Evolutionary applications · 2025Article
- Environmental Sources of Possible Associated Pathogens and Contaminants of Stingless Bees in the Neotropics.Insects · 2025Review
- Genotype B of deformed wing virus and related recombinant viruses become dominant in European honey bee colonies.Scientific reports · 2025Article
- Dominance of recombinant DWV genomes with changing viral landscapes as revealed in national US honey bee and varroa mite survey.Communications biology · 2024Article
- New insights into honey bee viral and bacterial seasonal infection patterns using third-generation nanopore sequencing on honey bee haemolymph.Veterinary research · 2024Article
- Molecular Characterization and Phylogenetic Analysis of Honeybee (Microorganisms · 2024Article
- Origins, diversity, and adaptive evolution of DWV in the honey bees of the Azores: the impact of the invasive miteVirus evolution · 2024Article
- Doomed drones? Using passage experiments and mathematical modelling to determine Deformed wing virus population dynamics in male honeybees.Proceedings. Biological sciences · 2023Article
- Review
- Interaction between the VP2 protein of deformed wing virus and host snapin protein and its effect on viral replication.Frontiers in microbiology · 2023Article
- Virus Prevalence in Egg Samples Collected from Naturally Selected and Traditionally Managed Honey Bee Colonies across Europe.Viruses · 2022Article
- Transmission of deformed wing virus between Varroa destructor foundresses, mite offspring and infested honey bees.Parasites & vectors · 2022Article
- Epidemiology of a major honey bee pathogen, deformed wing virus: potential worldwide replacement of genotype A by genotype B.International journal for parasitology. Parasites and wildlife · 2022Article
- Article
- Molecular Detection and Differentiation of Arthropod, Fungal, Protozoan, Bacterial and Viral Pathogens of Honeybees.Veterinary sciences · 2022Review
- A derived honey bee stock confers resistance to Varroa destructor and associated viral transmission.Scientific reports · 2022Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deformed wing virus (DWV) is considered one of the most damaging pests in honey bees since the spread of its vector, Varroa destructor. In this study, we sequenced the whole genomes of two virus isolates and studied the evolutionary forces that act on DWV genomes. The isolate from a Varroa-tolerant bee colony was characterized by three recombination breakpoints between DWV and the closely related Varroa destructor virus-1 (VDV-1), whereas the variant from the colony using conventional Varroa management was similar to the originally described DWV. From the complete sequence dataset, nine independent DWV-VDV-1 recombination breakpoints were detected, and recombination hotspots were found in the 5' untranslated region (5' UTR) and the conserved region encoding the helicase. Partial sequencing of the 5' UTR and helicase-encoding region in 41 virus isolates suggested that most of the French isolates were recombinants. By applying different methods based on the ratio between non-synonymous (dN) and synonymous (dS) substitution rates, we identified four positions that showed evidence of positive selection. Three of these positions were in the putative leader protein (Lp), and one was in the polymerase. These findings raise the question of the putative role of the Lp in viral evolution.
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