Evidence map›Paper›PMID 28120865›Full record

ArticleScientific reports2017

Leucine-Rich Repeat Kinase 2 (Lrrk2)-Sensitive Na

Zohreh Hosseinzadeh, Yogesh Singh, Derya R Shimshek, Herman van der Putten, Carsten A Wagner, Florian Lang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Decreased NaScientific reports · 2020
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Zohreh HosseinzadehDepartment of Cardiology, Vascular Medicine and Physiology, University of Tübingen, Gmelinstr. 5, D-72076 Tübingen, Germany.
Yogesh SinghDepartment of Cardiology, Vascular Medicine and Physiology, University of Tübingen, Gmelinstr. 5, D-72076 Tübingen, Germany.
Derya R ShimshekDepartment of Neuroscience, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.
Herman van der PuttenDepartment of Neuroscience, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.
Carsten A WagnerInstitute of Physiology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Florian LangDepartment of Cardiology, Vascular Medicine and Physiology, University of Tübingen, Gmelinstr. 5, D-72076 Tübingen, Germany.
University of Tübingen · DENovartis Institutes for BioMedical ResearchNovartis (Switzerland) · CHUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leucine-rich repeat kinase 2 (Lrrk2) has been implicated in the pathophysiology of Parkinson's disease. Lrrk2 is expressed in diverse cells including neurons and dendritic cells (DCs). In DCs Lrrk2 was shown to up-regulate Na

Indexed as

AnimalsCells, CulturedDendritic CellsFlow CytometryGene Expression ProfilingLeucine-Rich Repeat Serine-Threonine Protein Kinase-2MiceMice, KnockoutPatch-Clamp TechniquesReal-Time Polymerase Chain ReactionSodium-Potassium-Exchanging ATPaseLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Lrrk2 protein, mouseSodium-Potassium-Exchanging ATPase

Identifiers

PMID28120865
PMCPMC5264149
OpenAlexW2579937979

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.