ArticleJournal of exposure science & environmental epidemiology2017
Residential proximity to abandoned uranium mines and serum inflammatory potential in chronically exposed Navajo communities.
Article in Journal of exposure science & environmental epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of Environmental Health Outcomes in Selected American Indian and Alaska Native Populations.Journal of racial and ethnic health disparities · 2020Pooled it
- Characterization of Carcinogenic and Non-Carcinogenic Metal(loid)s in Water Within a Uranium-Mining-Impacted Region in Northwestern New Mexico, USA.International journal of environmental research and public health · 2026Article
- Waste fire surveillance: A case study using remote sensing data and IoT ground sensing for monitoring fires at waste management sites.Waste management (New York, N.Y.) · 2026Article
- Extracellular vesicle proteomic expression is influenced by mining tenure in former uranium miners.Environmental research · 2025Article
- Uranium Exposure, Hypertension, and Blood Pressure in the Strong Heart Family Study.Preventing chronic disease · 2025Article
- Zinc as a Mechanism-Based Strategy for Mitigation of Metals Toxicity.Current environmental health reports · 2025Review
- Spatial nonstationarity and the role of environmental metal exposures on COVID-19 mortality in New Mexico.Applied geography (Sevenoaks, England) · 2024Article
- Single Cell Analysis of Human Colonoids Exposed to Uranium-Bearing Dust.Environmental health perspectives · 2024Article
- T'ah kóó hóniidló, we're still HERE! Mining legacies, Indigenous health and innovative solutions.Frontiers in public health · 2024Article
- Origin Stories of the 'Grants Uranium District' in Northwestern New Mexico: Archives, Memoirs, and Exploratory Boreholes in the Production of Geological Regions.Engaging science, technology, and society · 2024Article
- US drinking water quality: exposure risk profiles for seven legacy and emerging contaminants.Journal of exposure science & environmental epidemiology · 2024Review
- Preterm Birth and Metal Mixture Exposure among Pregnant Women from the Navajo Birth Cohort Study.Environmental health perspectives · 2023Article
- Meteorological data source comparison-a case study in geospatial modeling of potential environmental exposure to abandoned uranium mine sites in the Navajo Nation.Environmental monitoring and assessment · 2023Article
- Serum autoantibodies and exploratory molecular pathways in rural miners: A pilot study.Journal of translational autoimmunity · 2023Article
- Metal mixture exposures and multiplexed autoantibody screening in Navajo communities exposed to uranium mine wastes.Journal of translational autoimmunity · 2023Article
- Diné-centered Research Reframes the Gold King Mine Spill: Understanding Social and Spiritual Impacts Across Space and Time.Journal of rural studies · 2023Article
- The immunotoxicity of natural and depleted uranium: From cells to people.Toxicology and applied pharmacology · 2022Review
- U(VI) binding onto electrospun polymers functionalized with phosphonate surfactants.Journal of environmental chemical engineering · 2022Article
- Radioactive releases from the nuclear power sector and implications for child health.BMJ paediatrics open · 2022Review
- The fate of inhaled uranium-containing particles upon clearance to gastrointestinal tract.Environmental science. Processes & impacts · 2022Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Members of the Navajo Nation, who possess a high prevalence of cardiometabolic disease, reside near hundreds of local abandoned uranium mines (AUM), which contribute uranium, arsenic and other metals to the soil, water and air. We recently reported that hypertension is associated with mine waste exposures in this population. Inflammation is a major player in the development of numerous vascular ailments. Our previous work establishing that specific transcriptional responses of cultured endothelial cells treated with human serum can reveal relative circulating inflammatory potential in a manner responsive to pollutant exposures, providing a model to assess responses associated with exposure to these waste materials in this population. To investigate a potential link between exposures to AUM and serum inflammatory potential in affected communities, primary human coronary artery endothelial cells were treated for 4 h with serum provided by Navajo study participants (n=145). Endothelial transcriptional responses of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and chemokine ligand 2 (CCL2) were measured. These transcriptional responses were then linked to AUM exposure metrics, including surface area-weighted AUM proximity and estimated oral intake of metals. AUM proximity strongly predicted endothelial transcriptional responses to serum including CCL2, VCAM-1 and ICAM-1 (P<0.0001 for each), whereas annual water intakes of arsenic and uranium did not, even after controlling for all major effect modifiers. Inflammatory potential associated with proximity to AUMs, but not oral intake of specific metals, additionally suggests a role for inhalation exposure as a contributor to cardiovascular disease.
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